ICA: internal carotid artery, MCA: middle cerebral artery, OEF: oxygen extraction fraction CT attenuation correction (AC) is a major clinical advantage of PET/CT. However, motion can induce artifacts because of misregistration of the CT attenuation map and emission data. The aim of this study was to investigate the effect of misregistration in cerebrovascular disease patients. We collected six patients who showed mismatch between clinical finding and 15 O gas PET/CT imaging, and confirmed dislocation less than 2 cm from initial position. Three patients showed decreased cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO 2 ) on the opposite side or ipsilateral side. The other patients showed an unexpected artifact on oxygen extraction fraction (OEF) map. These data suggest that misregistration can affect patient diagnosis with dependent on the degree of misregistration.
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