Non-covalent interactions, such as hydrogen bonding, electrostatic and hydrophobic interactions, universally exist in metalloenzymes, and play an important cooperative role on the enzyme activation or substrate catalytic processes. Recently, the metalloenzyme mimicking based on the supramolecular chemistry is progressing towards the biological functional simulation involving the metastable intermediate and the microenvironment of the active site. In this paper, the research of the metalloenzyme models constructed by the cyclodextrin, an important host in supramolecular chemistry, will be reviewed based on the literatures and our work.
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