Epidermotropic metastatic malignant melanoma (EMMM) can simulate a primary malignant melanoma (PMM). However, since therapeutic management can be dramatically different for these two lesions, care must be taken in evaluating them. We report a man with a history of a PMM on the scalp who has subsequently shown several black papules on the locoregional skin, one of which was diagnosed an EMMM. We found 23 cases of EMMM in the literature and reviewed them. It seemed probable that the recent work with a new immunohistochemical marker, anti-metallothionein antibody, provides some help to differentiate EMMM from PMM.
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