Introduction: Autism is a lifelong neurodevelopmental disorder impairs social reciprocity and communication. The incidence of autism has been rising at an alarming rate over the past three decades, although the prevalence seems to differ between countries. Aim: The aim of this Study is to investigate the effects of gluten-free casein freediet (GFCF)fortified with/out Sage (Salvia officinalis) orGinkgo (Ginkgo Biloba)as a possible aid in the improvement of neurological, behavioral, neurochemical and histopathological changes associated with autism.Methods: Agroup of pregnant rats received a single intraperitoneal injection of 600 mg/kg Valproic acid (VPA) then their offspring were randomly distributed into 4 groups each 5 rats as following;group 1: fed with standard diet (VPA-SD) and served as control positive,group 2: fed with GFCF diet(VPA-GFCF diet), group 3: fed with GFCF diet plusSage (VPA-GFCF+ Sage), and group 4: fed with GFCF diet (VPA-GFCF + Ginkgo), where five offspring from healthy pregnant rats (not injected with VPA), fed standard diet were served as control negative group, Therapeutic potential ware measured using;the feed efficiency ratio (FER), serum level of (SOD),(T.A.C), (GSH), (MDA) and (5-HT) in addition to histopathological study of the cerebellum. Results:results showed that diet with Ginkgo significantly illustrated the highest effect on the FER compared to all other groups (p<0.05).There weremild differences in serummarkers,where sage group expressed the highest effect followed by ginkgo and then the GFCF diet.
Currently dietary interventions become very critical widelyso it has been recommended for many diseases. e.g., patients with diabetes mellitus(DM), heart diseases, obesity, stroke and cancers should consume foods rich in flavonoid compounds in order to improve their health states. The current study carried out to investigate the effects of different levels of dietary Arabic Gum (AG)supplemented with Yogurt (Y) on diabetic health states using animal models. Thirty male rats were used and divided into six groups; the 1 st is the control healthy group (1) that fed on basal diet while the rest of all the groups were diabetic induced and one of them used as control positive group (2). Additionally, groups 3 &4 were fed basal diets supplemented with 5 % of either Y or AG each separately while group 5 was fed 5 % of mixed Y and AG on their diets. Body weight, blood glucose levels in addition to liver functions and pancreatic histopathology were evaluated after consuming the supplemented diets. Collected data showed that glucose levels were significantly decreased (P<0.05) after AG and Y consumptions. However, the highest effect has been seen with 5% concentration. Also, ALT and AST that were determined as liver functionswere significantly decreased (P<0.05) after AG consumption comparing to the positive diabetic group and the other tested groups. In conclusion, the obtained results suggested that AG is highly recommended with to be used as dietary medication especially at the level 5% for diabetic and hyperlipidemia patients. However, further human studies are needed.
The present study investigated the effects of some high protein sources on liver functions, lipid profile and immunoglubin index (IgA,IgA,IgG) in rats . Twenty one male albino rats were divided into (3) groups )7) rats in each group. The first group was control which fed on basal diet only as a negative control. The other groups were received basal diet containing 10% from formula 1 which contained beef protein and formula 2 contained whey protein .Liver functions was assessed by estimation of plasma concentration of enzymes activities of aspartate amino transferase (AST), alanine amino transferase (ALT), lipid fraction (total cholesterol and triglyceride) and cholesterol fraction (HDL-c, LDL-c, VLDL-c). Results showed bad effect of these protein source on the tested parameters and the beef protein group was the most group which affected by high level of high protein source. So, this study concluded that high intake of high protein sources for a long time led to increase the liver enzymes , lipid profile and decrease the immunity status in rats Key words: Beef protein, liver functions -cholesterol fractions. largest source of meat after poultry and pork (Hoffman et al.,2004) Amino acid composition of meat products can play a significant role in meat identification; the ratios of amino acids arginine, histidine and lysine for the investigated species of animals have been obtained. These ratios do not depend on age or weight of the animal (Weiss, et al., 2000). The chemical and nutritional composition of each meat product is greatly varied from one product to another as it contains different kinds of tissues and sometimes a mixture of meat of various organs(McClements et al. ,2010); Whey proteins are easily and quickly digested. Whey protein is one of the 2 proteins of cow's milk. Whey proteins refer to the individual protein which is separated out from the casein while cheese making. These proteins are purified into different concentrations based on the end composition desired )Mansour et al., 2000). The content of the whey protein may vary in carbohydrates, fat, immunoglobulins, lactose and minerals. Whey proteins are loaded with EAAs (Essential Amino Acids) including three BCAAs (Branched Chain Amino Acids) and also they contain subcomponents of micro fractions which provide the benefits of elemental nitrogen and amino acids. Whey protein is the one which is most useful for sports nutrition. In addition to these, whey products are evident in salad dressings, infant formulas, emulsifiers, baked goods and medical nutritional formulas )Tietzet al., 1976). Whey protein is considered as an excellent protein for the choice of individuals of all ages for healthy diet and also to improve and maintain their health. Traditionally, Whey protein was only used by most of the athletes and bodybuilders to promote the muscle growth. But from past few years, whey protein is being used in some other applications. Some applications that using whey proteins are: cancer treatment, wound healing, infant health and weight loss.Accor...
The present study was designated to evaluate the effect of bread supplementation with some vegetables powder (carrot, squash and spinach) on the healthy and physiological status of elderly rats. Forty white female Albino rats were divided into 8 groups rats (5 rats each), All groups were fed for 28 days on experimental diet as follows: negative control group was fed on standard basal diet, positive control group was fed on basal diet and 15% regular bread. Other groups were fed on experimental basal diet with 15% bread supplementated with 10% and 15 % of carrot and squash powder, 10% of spinach powder and 15% of mixture of them. At the end of the experiment, blood samples were collected for determining the following parameters: serum glucose, liver enzymes (AST, ALT, and ALP), kidney enzymes (creatinine and urea), and immunological profile test (IgE, IgM, IgA and IgG). Results showed that the best organoleptic evaluation was noticed in case of bread supplemented with carrot and squash at 10% and 15% level. Bread supplemented with 10 and 15% carrot, squash and 15% mix of them showed a significant decrease in blood glucose in rats groups. Liver enzymes showed a significant increase in AST, ALT in treated groups fed on 15% carrot, squash bread powder and mix of them. Also, ALP was improved in groups fed on 10% carrot and squash powder bread. As conclussion all treaded group parameters revealed a significant increase in immunological profile in elderly female rats.
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