Multidrug resistance and various adverse side effects have long been major problems in cancer chemotherapy. The discovery of bioactive components in foods is exciting, suggesting the possibility of improved public health through diet. Broccoli floret are an excellent source of health-promoting phytochemicals such as vitamins, glucosinolates, and phenolics. The present study aimed to examine the therapeutic effects broccoli powder to reduce the side effects of cisplatin chemotherapy in adult rats. Twenty four adult male albino rats were randomly divided into two main groups; the first main group served as a negative control and the second main group (18 rats(were injected with a single intraperitoneal dose of cisplatin (CP) (10 mg/kg of B.W.). This group were divided into three subgroups, subgroup 1 served as positive control group, subgroup 2 and 3 were fed on the diet containing 2.5% and 5% broccoli powder. After completing the treatment period, animals were sacrificed under diethyl ether anesthesia. Blood samples were collected for the biochemical analysis. Results showed that group rats fed on 5% broccoli floret recorded the highest effective to reduce SGPT, SGOT, ALP, T.P, TC and TG level compared with group rats fed on 2.5% broccoli floret. Also, 5% broccoli improvement all tested oxidative enzyme (SOD, NAD and CAT) was observed. In conclusion, group rats fed on 5% broccoli floret markedly the side effects of cancer patients treated with cisplatin.
Artichoke has been reported to be used internally for the treatment of inflammation of the intestinal mucosa. It has been claimed to act as an antioxidant. The objective of this study was added artichoke powder in baked products and its assessed the protective activity of artichoke against peptic ulcer which induced by ethyl alcohol in adult male rats. Artichoke was used to replace part of the whole wheat flour (2.5%, 5% and 10%) in standard cake. Appearance, taste, flavor, texture, color and overall acceptability were evaluated in cake .The results showed that groups which treatment with artichoke were significantly decreased in ulcer score, ulcer index and increase in preventive index compared with the positive control group. Supplemented rats diet with 10% of artichoke powder were more effective to protect the stomach of ulcer. Moreover sensory evaluation showed that all replacement of artichoke in cake were showed acceptable by the panelists. It concluded that artichoke had a protective activity against peptic ulcer in adult rats which induced by ethyl alcohol. Also, Thirty rats were randomly divided into five groups (n=6 for each), the first and second groups fed standard diet, from the third to the fifth groups fed standard diet containing 2.5, 5, 10% artichoke powder(AP). The rats of second to fifth groups were received a single orally dose of ethyl alcohol 90% at 10 ml/kg body weight. After two hour later and under anesthesia by diethyl ether, abdominal wall was opened, the pylorus identified, stomachs ligated from esophageal opening, removed, opened at greater curvature, gastric juice collected and centrifuged for studying of gastric secretion parameters.
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