B iological effects of succinic acid derivatives (DSA's) have been extensively studied. This fostered the elaboration on their basis of several original medicines capable of affecting different links of metabolic processes via enhancement of the organism's adaptive capacity, yet are relatively harmless. Succinic acid represents one of the basic metabolites of the tricarboxylic acid (TCA) cycle, and its derivatives (Lymonthar, Reamberine, Mexidol, Mexicore, Yaktone, Sufan etc.) belong to drugs of the metabolic action type that enhance energy metabolism and are capable of correcting the free-radical processes [1,2]. Among DSA's, researchers have identified compounds with the antioxidant, detoxifying, anti-hypoxic, anti-diabetic, anti-inflammatory, cardio-and hepatoprotective activity [3][4][5][6].It is known that DSA's serve as exogenous donors of an energy substrate, succinate, oxidation of which within the TCA cycle restores FADH 2 in structure of the succinate dehydrogenase; however, the actual electron acceptance (accompanied by the ATP synthesis) is accomplished by coenzyme Q in the mitochondrial respiratory chain. The stated compounds are able, at hypoxia conditions, to increase the activity of the succinate-oxidase way of oxidation as the compensatory metabolic flux that normali zes the intracellular pool of ATP and thus facilitates the aerobic energy supply [7]. Our colleagues have previously proved that succinate is a ligand of GPR91 receptor and acts as a signaling molecule that carries the intra-and intercellular interactions, positively influencing the energetic processes in cells. These data indicate an energotropic and anti-hypoxic activity of DSA's interconnected inter alia with their anti-diabetic, cardio-, hepatoand neuroprotective activity [8,9].A distinctive feature of DSA's covers their antioxidant activity which is manifested under oxidative stress and causes stabilization of the cell membranes and improvement of metabolic processes. It was found that therapeutic doses of sodium succinate and some other DSA's can reduce intensity of the lipid peroxidation (LPO), thus helping to restore the transport of electrons via a part of the respiratory
The paper studies the antioxidant potential of a pharmaceutical composition (PhC) based on cathiazine (a camphoric acid derivative with a sperm-stimulating action) and succinic acid within the paracetamol-induced hepatitis in rats. We determined the content of the lipids peroxidation (LPO) products, content of the stable nitric oxide metabolites and activity of the antioxidant system in the liver, serum or whole blood. Authors found that, when administered orally to rats with hepatitis, the PhC stimulated a glutathione unit of the antioxidant system as well as restored (up to a control level) the intensity of LPO processes, content of the nitrite and nitrate anions in the liver and whole organism, in such a way ensuring the functional state of the liver normalization. The obtained results testify good prospects of using the PhC with cathiazine + succinic acid as a hepatic protector with the pronounced antioxidant properties in correcting the general liver pathology and its combination with the impaired spermatogenesis.
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