Backgraund: Allergic rhinitis (AR) is a common IgE-mediated disease. Multiple mechanisms are involved in the regulation of IgE synthesis, and cytokines produced by immune cells play an important role in this process. In addition, the study of the features of immunological reactivity in seasonal AR (SAR) is of interest both getting of new data about pathogenesis of the disease and optimization of the treatment.
Aims: To study the features of the cytokine status and hematological parameters in patients with SAR outside the period of exacerbation.
Materials and methods: 43 adult patients with SAR (stage of remission) have been included in the study, and 47 conditionally healthy patients have formed the comparison group; perennial symptoms and/or sensitization to perennial allergens were considered as exclusion criteria. Complete blood cell count and serum IL-4, IL-5, IL-6, IL-8, IL-10, IL-18, MCP-1, total IgE, eosinophil cationic protein levels were measured.
Results: The remission stage in patients with SAR is characterized by higher serum levels of total IgE and IL-8 compared with the group of healthy patients. Normal serum total IgE level in patients with SAR in remission is associated with activation of the monocyte-macrophage link (increased serum levels of MCP-1, IL-6, IL-8, absolute and relative numbers of monocytes). Increased serum total IgE level is associated with the predominant signs of the Th2-phenotype of the immune response (increased in the serum levels of IL-4, IL-5).
Conclusions: Immune reactivity of patients with natural remission of SAR is characterized by Th1-phenotype features if serum level of IgE is normal and Th2-ones if IgE is increased.
The aim of the study is to research the effects of immunostimulant Ribomunyl in virus-induced bronchial asthma (VBA) children.Materials and methods. 14 virus-induced bronchial asthma (VBA) children were agministrated with immunostimulant Ribomunyl as a part of complex therapy in a 18-month trial (3 cycles of treatment). The comparison group consisted of 16 patients who received only standard therapy for bronchial asthma. At the end of the study, against the background of basic BA therapy, the following parameters were estimated: the frequency of acute respiratory viral infections (ARVI), the need for antibacterial therapy, the frequency of IgG to respiratory-syncytial virus (RSV) prevalence, the serum level dynamics of total IgE, IFN-γ, interleukin-4 (IL-4), interferon gamma (IFN-γ).Results. The inclusion of Ribomunyl into the basic therapy complex in virus-induced bronchial asthma (VBA) children, made it possible to reduce the need for the VBA basic therapy complex by 50% and by 12,5% (р=0,0279). At the same time, as for the frequency of acute respiratory viral infections (ARVI), there was a comparable decrease in both groups, but in the main group the number of cases requiring antibiotic therapy decreased from 78.6% to 42.9% (p=0.0199). The inclusion of Ribomunyl into the basic therapy complex resulted in the decrease of the total IgE serum level; in the patients with the initial presence of IgG to the respiratory syncytial virus (RSV), the IL-4 level decreased and the IFN-γ level increased.Conclusion. Ribomunyl improves the treatment of virus-induced bronchial asthma (VBA) children, herewith the dynamics of immunological indicators is more in RSV-seropositive patients.
One of the most relevant courses in modern immunology is studying of the importance of pro- and anti-inflammatory cytokines in an immune and inflammatory response. By this moment a lot of data regarding the cytokine status of certain inflammatory processes in gastrointestinal tract were received. But still many questions remain unanswered. Moreover, most of the research concern the studying of the level of cytokines in biopsy materials from different parts of gastrointestinal tract or from the gastric juice itself. This article presents the results of the study of the features of cytokines production in patients with combination of allergic rhinitis and H. pylori-associated diseases of the upper gastrointestinal tract. A total of 225 patients aged 18 to 40 years (mean age was 29,5 ± 6,74 years) were examined. The patients included into the research: 43 patients had allergic rhinitis, 66 patients had inflammatory diseases of the upper gastrointestinal tract (chronic gastritis/gastroduodenitis), 69 patients had allergic rhinitis with concominant inflammatory diseases of the upper gastrointestinal tract. Allocating patients to group was carried out depending on the presence of allergic rhinitis and H. pylori infection. Serum level of IL-6 and IL-8 and complete blood cell counts were evaluated. Statistical significance in difference of frequency in independent groups was determined by Fisher’s exact test or χ2 criteria. It was shown that serum values of IL-6 in H. pylori-negative patients were within the reference interval with single peaks, while the synthesis of this cytokine is significantly increased in patients with H. pylori infection regardless of the presence of allergic pathology. Frequency of elevated serum values of IL-8 were comparable in groups of patients with gastrointestinal diseases, but it was significantly higher than in group of healthy individuals. Interdependence between serum level of IL-8 and white blood cell count was found. This fact is an area of interest for prognosis of development of the inflammatory process. As a result, the serum level of IL-8 in inflammatory diseases of the upper gastrointestinal tract increased regardless of the presence of H. pylori infection and allergic rhinitis, and increase of serum IL-6 level was observed only in H. pylori-positive patients.
Background: “atopic march” (AM) is the natural history of allergy mostly in children.
The aim: to describe the production of biomarkers of allergic inflammation in dependence on the duration of AD.
Patients and methods. 94 children suffered from atopic dermatitis (AD) have been included to the study. The severity of the disease has been estimated, serum level of total IgE, IL-4, interferon gamma and sIL-2R have been estimated.
Results. Coexistence of AR and AD was diagnosed in 32/94 (34.0%) patients. Less severity of AD (SCORAD 32.3 ± 9.17 score vs 22.2 ± 2.29 score, p < 0.05), but higher serum level of total IgE (Ме 123 [Q1-Q3 67–156] IU/ml vs Ме 53 [Q1-Q3 5–108] IU/ml, р < 0.001), IL-4 (Ме 12.0 [Q1-Q3 8.7–16.1] pg/ml vs Me 6.0 [Q1-Q3 2.2–12.1] pg/ml, р = 0.0399) and sIL-2R (Ме 2.1 [Q1-Q3 0–20] IU/ml vs Me 0 [Q1-Q3 0–12.9] IU/ml, р = 0.3365) are detected in comorbid patients. Eposides of wheezing are associated with additional risk of AD (OR 2.3 [95% CI 1, 18–4,54]).
Discussion. The development of AR in children with AD is considered as progression of natural history of allergy. In our study it was associated with higher level of IgE, IL-4 and sIL-2R. At the same time the comorbid patients had less severity of AD.
Conclusion. The coexistence of AD and AR in 3-year-old children is associated with less severity of skin symptoms but higher frequency of sensitization to inhalant allergens than in AD. AM is accompanied by higher production of Th2-dependent parameters and markers of early activation of T-cells. The probability of the AM is higher in 2 times if there were wheezing episodes in the anamnesis.
This article presents the results of the study of the immune status of the patients with inflammatory diseases of the upper gastrointestinal tract depending on the presence of H. pylori infection and allergic rhinitis. A total of 65 patients aged 18 to 40 years were examined. The lymphocyte immunophenotype by CD markers, the level of IgM, IgA, IgG, circulating immune complexes, IL-4, IL-10, total IgE in serum were determined in all patients. It was revealed that the number of mature CD3+ lymphocytes increased while the number of CD22+ cells decreased in patients with H. pylori infection. In addition, the level of total IgE, IL-4, IL-10 in serum was reduced in this group of patients. The results of the study indicate that the presence of H. pylori infection in patients with allergic rhinitis is associated with a slightly different nature of immunological reactivity compared with monopathology (allergic rhinitis) and H. pylori-independent inflammatory diseases of the upper gastrointestinal tract.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.