The authors investigated the involvement of the adenosine triphosphate (ATF) in the mechanisms of plasticity in the striated muscle in condition of protein sensitization. Contractile function and non-quantum secretion of the acetylcholine in the endplate zone were studied in isolated skeletal muscles of mouse legs (musculus soleus and musculus extensor digitorum longus) and strips musculus diaphragm. The authors studied the soleus and diaphragm dynamics of the force vector of muscle contraction after effects of exogenous adenosine triphosphate correlated with changes non-quantum secretion of acetylcholine in all the experimental models. However, the extent of these changes in sensitized animals is less pronounced than in the controls. It is suggested that adenosine is a party change mechanisms and functional properties soleus and diaphragm at the protein sensitization. The basis of the development of resistance, stability to long as the external stress, and at the initial stages of the experimental allergic these muscles are dependent adenosine mechanisms regulating their sensitivity to acetylcholine. These processes provide a reduction in respiratory muscle fatigue in hypoxia that occurs in asthma, chronic obstructive pulmonary disease and broncho-spastic syndrome, as well in increase their performance during prolonged physical activity. The reasons for changes in the force reduction extensor digitorum longus at a protein sensitization doesn’t associated with the mechanisms of muscle excitation mediated by adenosine triphosphate.
Oxidative stress underlies the formation of the pathology of cardiovascular system in young athletes. Its potential role in the pathogenesis of myocardial remodeling in young athletes has been discussed. The paper is devoted to the study of the changes of free radical oxidation in the body by the method of chemiluminescence and antioxidant effect on the functional state of the cardiovascular system. The results of clinical studies on the antioxidant effect of polydihidroxyphenilenthiosulfonate sodium («Hypoxen») in vitro, namely the addition of a substance in a simple model systems that mimic the most common reactions of free radical oxidation in the organism, such as formation of reactive oxygen species and lipid peroxidation. It has been found in this study that concentration of free radicals in the blood in athletes with physiological manifestations of athlete´s heart and signs of stress cardiomyopathy has been increased. After administration of Hypoxen in vivo the concentration of free radicals in the athlete’s blood has been found to be reduced. In assessing the functional state of the cardiovascular system administration of Hypoxen resulted in the improved physical performance in young athletes. Maintaining of free radical oxidation processes at the optimal levels contributes to timely prevention of stress cardiomyopathy.
The article is devoted to the development of a mathematical model of cultivation technological process on the slopes through the use of a deformable model of continuous Newtonian medium. We cited some results of numerical implementation of the model for the duckfoot cultivator, plow body and disk working unit.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.