The aim of the study was to determine the role of foreign citizens registered in Moscow region, in the maintenance of the epidemic process of measles, rubella and mumps based on the basis of their susceptibility to these infections and compare with the control group (residents of the Russia Central Federal District - donors of blood). Materials and methods. Examination included 909 samples of blood sera obtained from migrant workers and 939 blood donors (residents of the Central Federal district of Russia) which were tested for the presence of antibodies (IgG) to measles, rubella and mumps with the help of enzyme-linked immunosorbent assay. Results. Average relative density of seronegative persons among the surveyed migrants and donors to rubella virus ranged from 6.6 to 9.8%, the measles virus - 13.5 and 16.5%, respectively, statistically significant distinctions in groups were not established. The proportion of seronegative persons to mumps virus twice and more exceeded the standard documentation level among migrants and donors (32.5 and 47.5% respectively). Conclusion. There was a significant excess of the permissible level of seronegative persons to the measles, rubella and mumps viruses among migrant workers and blood donors, which creates preconditions for maintenance of epidemic process and dictates the necessity of carrying out the corrective vaccination (or revaccination) of non-immune persons
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