The aim of the study was to establish the diagnostic significance of biochemical parameters, considered as markers of epileptic seizures in patients with arterial aneurysms (AA). 82 patients with AA (50.4 ± 11.5 year-old) with epileptic seizures (35 persons) and without them (47 persons) were examined. Before treatment, the following biochemical parameters were determined in plasma of patients: lactate, pyruvate, products reacting with thiobarbituric acid (TBA-P), antioxidant activity of the serum, activity of superoxidedismutase and catalase, tumor necrosis factor-alpha (TNF-ά). To characterize the diagnostic significance of the results, the diagnostic sensitivity and the diagnostic efficacy were determined. The complex of biochemical tests with high diagnostic significance, consisting of lactate, lactate/pyruvateindex, catalase activity, TBA-P and TNF-α, was established in patients with AA with epileptic seizures. It allows considering these parameters as markers of epileptic seizures development in patients with AA. Among the most diagnostically significant tests for detection of epileptic seizures in patients with AA should be considered the concentration of TNF-ά with diagnostic sensitivity of 73%, the diagnostic specificity of 79% and the diagnostic efficacy of 75%.
The article presents data assessment of the severity of the clinical condition and a number of biochemical parameters in 51 patients with aneurysmal intracranial hemorrhage on the 10th day, on average, after the rupture of the arterial aneurysm and after treatment with the additional use of magnesium sulfate to standard therapy in the postoperative period. It is shown, that at the time of hospitalization, 75 % of patients in the control group and 50 % of patients in the main group had cerebral vascular spasm according to transcranial dopplerography; activation of lipid peroxidation processes, a decrease in superoxide dismutase activity, an increase in the content of vascular endothelial growth factor and highly sensitive C-reactive protein (CRP) with a decrease in the level of stable nitrogen monoxide exchange products were detected. A statistically significant improvement in the clinical condition of patients on the Hunt-Hess scale, the modified Fisher scale, and an increase in the score on the Glasgow coma scale with normalization of pro- and antioxidant status of the blood were revealed in the main group after neurosurgical treatment and course use of magnesium sulfate. At the same time, high levels of highly sensitive CRP and low levels of nitrates/nitrites in the patients blood of both groups are maintained. Consequently, the additional use of magnesium sulfate improves the clinical condition of patients with intracranial hemorrhage and increases the antioxidant potential of the blood in the postoperative period.
The study of macro-and microelements in the blood and hair was carried out in 91 patients with ischemic stroke and 24 practically healthy persons, the results of which were taken as normal. It was found that in the blood of patients with ischemic stroke, the concentrations of magnesium, iron, copper, lithium, and aluminum are reduced, and a decrease in the levels of calcium, magnesium, iron, copper, and zinc in the hair was revealed. It has been shown that calcium, magnesium, zinc, and iron in hair have high diagnostic sensitivity, specificity, and efficiency (more than 60%) in ischemic stroke and they can be used as additional informative chemical markers of this pathology.
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