This article summarises the data of epidemiology, etipathogenesis, a clinical picture, diagnosis and the treatment of osteoma cutis. The classification, a histological picture, the place of osteoma cutis from the point of view of the phenotype in relation to the information of the world literature are presented. Osteoma cutis is a rare benign disease characterised by the formation of the bone tissue in the dermis or subcutaneous fat. Two theories of the origin of osteoma cutis are of particular interest: the result of fibroblast metaplasia into osteoblasts or the differentiation of primitive mesenchymal cells into osteoblasts and their migration to an ectopic site. Diagnosis and differential diagnosis are based on the clinical examination, measurement of calcium, parathyroid hormone, x-ray and skin biopsy. The differential diagnosis involves many dermatoses, including ossified hair follicle, osteosarcoma, epidermoid cysts, fibromas, neurofibromas, basal cell carcinoma, etc. The approach to the treatment is to use non-invasive or invasive methods: tretinoin cream, dermabrasion and punch biopsy, YAG laser, scalpel excision, curettage and CO2 laser. We consider skin osteoma to be an underestimated dermatosis, since we have not found descriptions of such cases in reviews in the available Russian literature.
The review presents data from foreign and domestic clinical studies on the efficacy and safety of microneedling application in the treatment of post-acne symptom complex. An analysis of the database of systematic reviews of Russian, European, American researchers, comparative studies on the effectiveness of the microneedling therapy in patients with different skin types for the treatment of postacne symptom complex is presented. Possibilities of microneedling monotherapy and variants of combined treatment, in particular the combinations of microneedling with PRP-therapy, acid peels, non-ablative lasers, injection gels (PMMA-collagen, hyaluronic acid, sodium succinate) are shown.
In this article we summarized etiopathogenesis and clinical data, presented classification and described diagnosis challenges. One of the most common epithelial tumors, keratoacanthoma (KA) is characterized by rapid growth, histopathological features of squamous cell skin cancer and spontaneous regression tendency. Differential diagnosis of typical and atypical KA can be challenging since an early stage atypical KA may present similar to typical KA. Immunomorphological and immunohistochemical methods are particularly relevant for detecting atypical KA, making it possible to reliably differentiate it from squamous cell skin cancer. Years of experience in the management of KA patients, as well as foreign researchers data, suggest that the treatment approach should be based on the differentiation of clinical features of a typical KA from an atypical one.This report describes a clinical case of a giant keratoacanthoma.
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