Despite the outstanding results of treatment using autologous chimeric antigen receptor T cells (CAR-T cells) in hematological malignancies, this approach is endowed with several constraints. In particular, profound lymphopenia in some patients and the inability to manufacture products with predefined properties or set of cryopreserved batches of cells directed to different antigens in advance. Allogeneic CAR-T cells have the potential to address these issues but they can cause life-threatening graft-versus-host disease or have shorter persistence due to elimination by the host immune system. Novel strategies to create an “off the shelf” allogeneic product that would circumvent these limitations are an extensive area of research. Here we review CAR-T cell products pioneering an allogeneic approach in clinical trials.
<p>The purpose of our work is to check the effectiveness of the principle of systematic in the process of teaching professional foreign language to the engineering specialties. The laboratory work contains information lexical programs for the introduction of active lexical lessons, vocabulary and grammar exercises, and questions to the texts of lessons, designated for self-control and mutual control. The authors presented the results of the implementation of the system principle in the pedagogical process, namely the possibility of providing systematic construction of methodical literature and construction of intra subject links. The laboratory work, thanks to which there is an actualization and improvement of basic knowledge and skills, as well as the motivation of educational activity - is the form of realization of this principle. The students have an opportunity to demonstrate the independence in performing communicative actions in the professional sphere, provided by the program, to automate their skills, to conduct the self-study and self-monitoring of knowledge and skills, as well as to make their correction.</p>
The study aims to reveal the attitude of students and teachers to mobile learning; explore the possibility of developing critical thinking skills in mobile learning; and also evaluate knowledge after a short training course involving the use of mobile technologies in the context of the development of critical thinking. The research relies on an interview and a test. It was attended by 275 people (93 teachers and 182 students). The results showed that 58% of teachers and 55% of students believe that mobile learning does not contribute to the development of critical thinking. The test results showed that the study participants who pre-listened to the course of lectures on their mobile devices did not cope with the questions well enough, and cognitive errors were identified. The research has shown that improving the skills of interpreting, analyzing, evaluating and explaining information can increase the effectiveness of mobile learning. The research is a contribution to the study of various aspects of the impact of mobile learning on students and will be of interest to teachers, students, academic administration, parents, as well as to those who are interested in modern pedagogy and educational psychology.
Under. In this paper, the author characterizes the conceptual foundations of building the philosophy of the bio-elelectic sphere as a theoretical construct, which development will allow revealing the essential aspects of the strategy of rational socio-natural development, determining the directions for its subsequent implementation. "Biotelectectosphere (bios - life, sphaira - sphere, Latin intellectus - intellect) – the sphere of intelligent organization of life – the stage of development of the biosphere, where human activity will be aimed at preserving and maintaining the conditions necessary for the optimal existence of life – the geological factor, which is the initial prerequisite for the emergence and existence of mankind
Смирнов Сергей Владимирович Охранительная и рационально-образовательная деятельность как фактор сохранения и воспроизводства биосферы В представленной статье автор характеризует основные направления реализации охранительной и рациональнопреобразовательной деятельности человека: организацию особо охраняемых природных территорий, использование технологий энерго-и ресурсосбережения. Подчеркивая позитивные сдвиги, имеющие место в реализации подобных шагов, автор отмечает, что в условиях сохранения потребительских приоритетов мышления и деятельности усилия мирового сообщества, направленные на сохранение и рациональное использование природных благ, сводятся на нет.
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