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We prove that the one-dimensional heat equation with memory cannot be controlled to rest for large classes of memory kernels and controls. The approach is based on the application of the theory of interpolation in Paley-Wiener spaces.

Delineation of hydrocarbon prospective areas is an important issue in petroleum exploration. The geoelectric method helps to identify attractive areas and reduces the overall drilling risk. For this purpose, induced polarization (IP) effects are mapped caused by the presence of epigenetic pyrite microcrystals in sedimentary rocks. These crystals occur in a shallow halo-shaped mineralogical alteration zone, often overlying a deeper-seated hydrocarbon accumulation. Local enrichment in pyrite results from reducing geochemical conditions below an impermeable layer. The imperfect top seal of the accumulation permits minor amounts of hydrocarbons to escape and migrate through the overlying rocks to shallower levels. During migration, hydro-carbons encounter an impermeable barrier, forming an altera-tion zone. Induced polarization logging and coring in wells confirm this working model. Geoelectric surveying visual-izes anomalies in electric potential difference measured be-tween receiver electrodes. The differentially normalized method (DNME) inverts the registered decay in potential differences, establishing a depth model constrained by seismic and petro-physical data. Diagnostic geoelectric attributes are proposed, giving a better grip on chargeability and resistivity distribution. Acquisition and processing parameters are adjusted to the target depth. Encouraging results are obtained in deeper [Formula: see text] as well as in very shallow water. Onshore, a grounded current transmitter is used. Geoelectric surveys cover different geologic settings with varying target depths. The success ratio for predicting hydrocarbon occurrences is high. So far, 40 successful wells have been drilled in Russia on mapped geoelectric anomalies. Out of 126 wells, the method produced satisfactory results in all but two cases. The technique reduces the risk attached to new hydrocarbon prospects and allows better ranking at a reasonable cost.

Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal cells (MSCs) application. However, recent experience has accumulated numerous reports of adverse events and side effects associated with MSCs therapy. Furthermore, the strategies and methods of MSCs therapy did not change significantly in recent decades despite the clinical impact and awareness of potential complications.An extended understanding of limitations could lead to a wider clinical implementation of safe cell therapies and avoid harmful approaches. Therefore, our objective was to summarize the possible negative effects observed during MSCs-based therapies. We were also aimed to discuss the risks caused by weaknesses in cell processing, including isolation, culturing, and storage. Cell processing and cell culture could dramatically influence cell population profile, change protein expression and cell differentiation paving the way for future negative effects. Long-term cell culture led to accumulation of chromosomal abnormalities.Overdosed antibiotics in culture media enhanced the risk of mycoplasma contamination. Clinical trials reported thromboembolism and fibrosis as the most common adverse events of MSCs therapy. Their delayed manifestation generally depends on the patient's individual phenotype and requires specific awareness during the clinical trials with obligatory inclusion in the patient' informed consents. Finally we prepared the safety checklist, recommended for clinical specialists before administration or planning of MSCs therapy.

Abstract.A hybrid system, composed of an elastic beam governed by an Euler-Bernoulli beam equation with variable coefficients and a linked rigid body governed by an ordinary differential equation, is considered. Various controllability/observability properties of the system under bounday control/observation are studied. It is shown that an open-loop smooth/singular controller of either torque control or force control is sufficient to make the system exactly controllable in arbitrarily short time duration.

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