In the present work, in the framework of solving the problem of obtaining a new generation of materials with a set of properties not inherent in traditional metal and non-metal types, the practical necessity of developing a unified approach to designing their structure and properties is substantiated. Within the framework of the paradigm of multi-level structural organization of materials, based on a single model of chemical bonding, a generalization of physicochemical prrinciples was carried out, revealing the unity of nature and the causes of differences in the structure and properties of metallic and non-metallic substances and materials. Through the effects of the ratio of the components of the chemical homo - or heteronuclear interaction of the elements of the fine microstructure of substances and materials on the differences in subsequent levels of the structure (molecular and non-molecular, etc.) and properties (conductor-dielectric, ductile, elastic or fragile and hard, etc.) of metals and nonmetals the practical significance of the scientific approach developed in the work was shown.
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