Annotation. The level of subjective control may vary in different regions depending on social and economic living conditions, moral attitudes and level of education of the population. Circumstances such as age, gender and constitutional variability in the locus of control cannot be ruled out (although there is very little research on this issue). The purpose of the study is to conduct a comparative study of the typological delineation of the emotional-dynamic pattern in practically healthy Ukrainian women without and taking into account the somatotype. Primary anthropo-somatotypological and personality indicators of practically healthy Ukrainian women aged 21 to 35 of different somatotypes were selected from the database of materials of the research center of National Pirogov Memorial Medical University, Vinnytsya. Determination of the components of internality by J. Rotter in the modification of E. F. Bazhin, S. O. Golinkina and O. M. Etkind included the definition (sten): indicator of the scale of general internality of the level of subjective control, indicators of the level of subjective control in the industry achievements, failures, family relationships, educational (professional) relationships, interpersonal relationships, health and disease. Statistical processing of the results was performed in the license package “Statistica 5.5” using non-parametric evaluation methods. The reliability of the difference between the values between the independent quantitative values was determined using the U-Mann-Whitney test. There was a lower level of general internality and subjective control in the field of achievement in mesomorphic women compared to women without taking into account somatotype and women of other somatotypes. According to the scale of internality in the field of failures in women without taking into account somatotype, endo-mesomorphs and representatives of the middle intermediate somatotype, the most developed sense of control over negative situations and the tendency to blame themselves for trouble compared to mesomorphic women. It is characteristic that in the sphere of family relations this image emerges especially clearly in mesomorphic women; they consider their partner, not themselves, to be more responsible for the events of family life. Women of intermediate somatotype compared to women without somatotype and women mesomorphs and ectomorphs have a higher level of internality in the field of interpersonal relationships. The level of subjective health and disease control in endo-mesomorphic women is significantly lower than in ectomorphic women. Thus, the level and various parameters of subjective control can be used as personal markers of the studied somatotype, which will create optimal and most individualized recommendations for psychological support, adaptation and coping strategies.
Мета. Дослідити імуногістохімічні зміни в шкірі хворих із псоріазом для прогнозування можливого загострення шкір- ного псоріатичного процесу після виконання оперативного втручання.
Матеріали і методи. Проведено імуногістохімічне дослідження біопсійного матеріалу, взятого з ділянок шкірної псо- ріатичної висипки та інтактної шкіри у хворих із псоріазом до виконання оперативного втручання. Крім того, для по- рівняння результатів імуногістохімічних досліджень вивчено біопсійний матеріал шкіри передньої черевної стінки, взятий у 5 практично здорових осіб відповідного віку після герніопластики. Для оцінки характеру та поширеності міс- цевих клітинних імунних і запальних реакцій у шкірі хворих із псоріазом застосовували імуногістохімічні методики з визначенням експресії маркерів імунного запалення.
Результати. Представлені результати дослідження змін імуногістохімічної експресії прозапальних біологічних мар- керів у шкірі хворих із псоріазом до виконання оперативного втручання з подальшим аналізом впливу такого стресо- вого фактора, як оперативне втручання, на перебіг шкірного псоріатичного процесу.
Висновки. Доведено, що одним із механізмів загострення запальних реакцій у хворих із псоріазом є активація імуно- компетентних клітин, зокрема через Toll–рецептори, що дає можливість скоригувати тактику лікування пацієнтів у піс- ляопераційному періоді.
Background. The objective was to study the peculiarities of cellular and humoral immunity in patients with chronic obstructive pulmonary disease (COPD) group B and C, GOLD 2–3, who have signs of metabolic syndrome (MS) and Herpesviridae infection. Materials and methods. Forty-two patients with B and C groups of COPD, GOLD 2–3, associated with MS were examined. Eighteen individuals had COPD combined with MS, and Herpesviridae infection. The average age of patients was 51.3 ± 4.2 years. The comparison group included 24 people with COPD and MS without signs of Herpesviridae infection. All patients underwent determination of herpes simplex virus (HSV) type 1 and cytomegalovirus (CMV) antigens in the blood and saliva, titer of specific immunoglobulin (Ig) G and IgM antibodies to HSV type 1 and CMV, a comprehensive immunological examination with a study of cellular and humoral immunity indexes, cytokine status. Results. The study of the activity of herpes viruses in the blood of patients of the main group did not reveal active replication of HSV type 1 and CMV; in the saliva of 15 individuals (83.3 %), an active replication of HSV type 1 was detected, and in 12 people (66.7%) — of CMV. All patients in the main group had a severe course of Herpesviridae infection with an exacerbation rate of more than 6 times a year. The immunological status of patients of the main group showed immunodeficiency mainly of T-cell immune system and NK-cells, a significant increase in the relative number of T- and B-lymphocytes with early and late markers of activation on the background of autoimmune manifestations and inflammatory changes in peripheral blood. Conclusions. The presence of chronic persistent infection of HSV type 1 and CMV causes a severe course of COPD associated with MS, induces the development of infectious exacerbations of COPD and more significant manifestations of systemic inflammation in atherosclerosis as a morphological substrate of MS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.