A tetrabromo derivative of arglabin was synthesized stereoselectively. The molecular structure of the new compound was established using PMR and 13 C NMR spectra and an x-ray structure analysis. Its antifungal activity was demonstrated.Arglabin (1) is a guaiane-type sesquiterpene lactone that was isolated from Artemisia glabella Kar. et Kir. [1]. New derivatives of arglabin were prepared by reacting dibromocarbene derivative 2 [2] with Br 2 in CHCl 3 to produce in quantitative yield the colorless crystalline compound 3 of formula C 16 H 18 O 3 Br 4 .
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