Background. Mycoplasma pneumoniae is included in the group of atypical pathogens of acute respiratory diseases. Mycoplasma pneumoniae is characterized by a tendency to prolonged course with progressive changes in the lungs. Main value in the confirmation of mycoplasma infection has microbiome in biosubstrates selection and serological diagnostics: the determination of specific immunoglobulins IgM or IgG in the dynamics to M. pneumoniae. Antibacterial therapy of mycoplasma pneumonia is prescribed based on the sensitivity of the pathogen to them. The duration of antibiotic treatment of mycoplasma pneumonia is determined by the dynamics of clinical and radiological data. Materials and methods. The article describes the features of the clinical course of mycoplasma pneumonia in a patient with tubinfection proceeding with bronchoadenitis and obstruction of the bronchus, which necessitated a differential diagnosis with tuberculosis of the intrathoracic lymph nodes and the appointment of repeated courses of antibiotic treatment.Results. In the described clinical case, the duration of Mycoplasma infection exceeded 3.5 months, during which time the patient received several courses of antibiotics. Mycoplasma pneumonia had a prolonged course, accompanied by bronchoadenitis.Conclusion. Our observations show the need to study the effectiveness of extended courses of antibiotics from the azalid group in the treatment of prolonged and complicated forms of Mycoplasma pneumonia.

BACKGROUND: Cystic fibrosis is one of the most frequent monogenic diseases, in which, in addition to medical measures, measures for the prevention of the infectious process in the lungs are of great importance, which is provided by a clear organization of the work of any medical institution where patients are observed and where medical and rehabilitation measures are carried out. AIM: The article describes the experience of the childrens Center in St. Petersburg to prevent cross-infection of patients with cystic fibrosis who have the different luge microbiome. MATERIALS AND METHODS: The measures taken included a system for monitoring and dynamic control of the seeded pathogenic microflora with a strict separation of patients with cystic fibrosis, who had the isolation and carriage of various pathogens. The system provided for the separation of flows of patients with cystic fibrosis and the prevention of cross-infection, as well as a number of activities related to the disinfection of equipment. RESULTS: The methods adopted and put into practice have ensured the prevention of cross-infection of patients with cystic fibrosis, excreting various pathogenic bacteria from sputum. The patient management system made it possible to halve the number of hospitalizations of patients with Pseudomonas aeruginosa infection per CF patient per year: from 1.3 in 2001 to 0.6 in 2021, reduce the risk of cross-infection, reduce the number of relapses, hospitalizations and the average length of stay of a patient in a hospital. CONCLUSIONS: The developed system of assistance has shown its effectiveness and can be implemented in one form or another in the work of cystic fibrosis treatment centers in the Russian Federation.