Using the molecular dynamics and molecular docking techniques, we have refined the dynamic dimer-ofdimers structures of the WT, S31N and V27A variants of the M2 proton channel of the influenza A virus, analyzed the inhibitor binding sites, identified a number of potential broad-spectrum inhibitor structures targeting them, and clarified the binding modes and probable mechanisms of action of one promising compound. The proposed approach is also suitable for the design of ligands interacting with other multiple labile targets.
The article analyzes vertical lathes from a retrospective point of view, defines the stages of formation and development of such machines. The advantages of vertical lathes are analyzed, and an attempt is made to find out the prospects for the development of such machines. The purpose of this work is to clarify the scope of rational use of vertical lathes. The results of calculations proving the advantages of such machines in terms of saving production space in comparison with the horizontal layout are presented.
This paper presents the results of a numerical study of synchronization of pendulums, chronometers, and mechanical clocks suspended from a common movable beam. An auxiliary problem is considered about the oscillations of a pendulum with a swinging weight, then the mutual synchronization of free vibrations of two and four pendulums (and pendulums with the supply of a moment pulse-clock) on a common movable spring-loaded beam. It is shown that in the considered simplest configuration, mutual synchronization (equality of frequencies or oscillation periods) is performed with high efficiency. The frequency of synchronized oscillations of the pendulums is close to the frequency of vibrations of the platform in a wide range of changes in its rigidity. The degree of connectivity of pendulums and synchronization of their oscillations is determined by the Strouhal number. Synchronization of clocks does not guarantee the accuracy of their movement, which is achieved only when the Strouhal number is equal to one.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.