The aim of the study was to establish the relationship between factors of metabolic‑associated diseases and markers of premature aging and biological age in patients of different age groups.
Materials and methods. The study included 151 patients with metabolic disorders but without clinical signs of cardiovascular disease, who were hospitalized or obtained outpatient treatment in the L. T. Mala National Therapy Institute of NAMS of Ukraine during the period of 2019 to 2021 years. The average age of the surveyed was 51.4 ± 12.1 years, women accounted for 62.3 % (n = 94). All patients were divided into groups depending on age: group 1 included subjects aged less than 40 years (n = 22), group 2 consisted of 40 to 49 years old (n = 46), group 3 — from 50 to 59 years (n = 49), group 4 — from 60 to 69 years (n = 21), group 5 — from 70 to 79 years (n = 13). All subjects underwent anthropometric measurements, clinical and biochemical analyses. Serum levels of insulin, C‑reactive protein (CRP), sirtuin 1 (SIRT1) and the percentage of global methylation based on the level of 5‑methylcytosine (5‑mc) were determined by enzyme immunoassay. Activity of total superoxide dismutase (T‑SOD) in blood serum was determined by colorimetric method. The prooxidant‑antioxidant balance of blood serum was calculated as the ratio of the levels of total hydroperoxides (THP) and total antioxidant activity (TAA). Molecular genetic studies included the determination of the relative telomere length of blood leukocytes by real‑time PCR. The epigenetic age was calculated using the DNAm PhenoAge epigenetic clock. Comparison of statistical characteristics between groups and over the course of observation was carried out using parametric and nonparametric criteria, depending on the type of data. Method of logistic regression was used to assess the prognostic value of the observed factors. For all types of analysis, differences were considered statistically significant at p < 0.05.
Results. The greatest amount of metabolic pathology and the least amount of isolated pathology were observed in patients aged 50 — 59 years. In this group of patients an analysis of age‑related features of metabolic disorders established a non‑linear parabolic dependence with a maximum of manifestations. Correlation analysis revealed a significant relationship between the percentage of global methylation and anthropometric indicators (body mass index, waist and hip volume, visceral fat percentage), platelet levels and glomerular filtration rate. Factors associated with the accelerated aging included insulin resistance index, total cholesterol, SIRT1, glycohemoglobin, and blood telomere length.
Conclusions. The acceleration of aging processes is associated with both metabolic and molecular genetic factors, this finding opens opportunities for predicting and timely prevention of age‑related diseases.
The article is devoted to the monograph "Political Criminology" (2017) of the Ukrainian scientist O. Bandurka. This work is presented as a scientific response to the aberrations of political consciousness that accompany the political and social processes in the modern Ukraine. Within this article are highlighted some individual concepts of the scientist's worldview and are presented his interpretation of the concepts of “power”, “political elite”, “political crime” etc. from the standpoint of public administration. The potentiality of O. Bandurka's "Political Criminology" outlined as a source for research in the field of Public Administration, Public Administration Theory and History and the other areas of Scientific Knowledge.
The paper has investigated the human rights activities of the State authorities of the constituent entities of the Russian Federation in the context of small indigenous peoples as persons having constitutional and legal status and a higher level of guarantees than ordinary citizens have because of their paucity. The author questions the independence of local laws from the State authorities of the constituent entities of Russian Federation using comparative analysis of regional laws of the Republics of Buryatia, Sakha (Yakutia), Kamchatka and Krasnoyarsk Regions with regard to appointment of ombudsmen to their offices, remuneration and financial support from regional budgets. The circumstances under consideration together with the lack of uniform approaches to the scope and nature of the functional instruments of authorized persons have served as the basis for the development of recommendations to coordinate their activities, to adjust the legal framework of the constituent entities of the Russian Federation in terms of requirements for applicants, and the scope of powers assigned to enforce human rights potential that are of practical importance and can be used by the authorities in in their rule-making work.
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