The article discusses the safety issues of a bioactive concentrate of small sea fish (BCSSF, Alflutop®) in the treatment of osteoarthritis (OA). The data of original studies, which were published during 2001–2021 years, from eLIBRARY, PubMed and Web of Science databases were analyzed. The selection of studies was carried out according to the following criteria: diagnosis of OA or nonspecific back pain; follow-up duration ≥1 month; intramuscular or intra-articular route of BCSSF administration; ≥30 study participants; availability of information about adverse events.The accumulated data confirm the safety of BCSSF, including in patients with high comorbidity. The drug has no significant effect on serum levels of glycemia, electrolytes and protein metabolism. These results indicate the possibility of widespread use of this drug in the treatment of OA of peripheral joints and spine in patients with comorbid diseases.
There is currently no approved list of vascular cognitive impairment biomarkers. The main problem for the practitioner in identifying cognitive impairment in patients is the differential diagnosis of Alzheimer's disease, vascular cognitive impairment, and other diseases, which are much less common. Vascular cognitive impairment includes post-stroke dementia, cognitive dysfunction in cardio-and cerebrovascular diseases. Without etiology identification, it is impossible to prescribe adequate treatment. Another challenge is identifying cognitive impairment before dementia develops. This literature review is devoted to the search and critical analysis of candidates for biomarkers of vascular cognitive impairment and the establishment of markers of moderate cognitive dysfunction. The papers were searched for in the Web of Science and PubMed databases. A list of cerebrospinal fluid, plasma, serum and genetic biomarkers was made, allowing for differential diagnosis between vascular impairment and Alzheimer's disease. The markers of moderate cognitive dysfunction, which make it possible to identify cognitive impairment at the pre-dementia stage, were also identified.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.