The analysis of the state of the problem on the sarcoidosis of the respiratory organs at the present stage has been carried out. The aspects of sarcouidosis immunopathogenesis are considered. Attention is focused on the variability of clinical and morphological manifestations and the expediency of identifying clinical and morphological phenotypes of sarcoidosis.In the differential diagnosis of tuberculosis and sarcoidosis, a comprehensive study of biopsy specimens is recommended, including a morphological study and a molecular study for mycobacterium tuberculosis. The negative result of a molecular study of a tissue substrate improves the accuracy and reliability of morphological verification of sarcoidosis.
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