The problem of nosocomial infections is growing due to the introduction of new treatment regimens involving immunosuppressive drugs. The genomes of seven Gram-negative clinical isolates of Escherichia , Klebsiella , and Pseudomonas were sequenced and analyzed in this study to serve as model microorganisms to study drug-induced antibiotic resistance reversion.
The appearance of drug-resistant pathogens reduces the therapeutic applicability of antibiotics and increases the rate of hospital infections among patients. Complete genome sequences of four Gram-positive clinical isolates of Streptococcus and Staphylococcus were obtained and analyzed to serve as model microorganisms for further studies on drug-induced antibiotic resistance reversion.
Bulletin the National academy of sciences of the Republic of Kazakhstan 2 NAS RK is pleased to announce that Bulletin of NAS RK scientific journal has been accepted for indexing in the Emerging Sources Citation Index, a new edition of Web of Science. Content in this index is under consideration by Clarivate Analytics to be accepted in the Science Citation Index Expanded, the Social Sciences Citation Index, and the Arts & Humanities Citation Index. The quality and depth of content Web of Science offers to researchers, authors, publishers, and institutions sets it apart from other research databases. The inclusion of Bulletin of NAS RK in the Emerging Sources Citation Index demonstrates our dedication to providing the most relevant and influential multidiscipline content to our community. Қазақстан Республикасы Ұлттық ғылым академиясы "ҚР ҰҒА Хабаршысы" ғылыми журналының Web of Science-тің жаңаланған нұсқасы Emerging Sources Citation Index-те индекстелуге қабылданғанын хабарлайды. Бұл индекстелу барысында Clarivate Analytics компаниясы журналды одан əрі the Science Citation Index Expanded, the Social Sciences Citation Index жəне the Arts & Humanities Citation Index-ке қабылдау мəселесін қарастыруда. Web of Science зерттеушілер, авторлар, баспашылар мен мекемелерге контент тереңдігі мен сапасын ұсынады. ҚР ҰҒА Хабаршысының Emerging Sources Citation Index-ке енуі біздің қоғамдастық үшін ең өзекті жəне беделді мультидисциплинарлы контентке адалдығымызды білдіреді. НАН РК сообщает, что научный журнал «Вестник НАН РК» был принят для индексирования в Emerging Sources CitationIndex, обновленной версии Web of Science. Содержание в этом индексировании находится в стадии рассмотрения компанией Clarivate Analytics для дальнейшего принятия журнала в the Science Citation Index Expanded, the Social Sciences Citation Index и the Arts & Humanities Citation Index. Web of Science предлагает качество и глубину контента для исследователей, авторов, издателей и учреждений. Включение Вестника НАН РК в Emerging Sources Citation Index демонстрирует нашу приверженность к наиболее актуальному и влиятельному мультидисциплинарному контенту для нашего сообщества.
swabs were collected from children under 17 years of age (60.75%). In 702 samples (9.85%) pathogens of respiratory infections of non-influenza etiology were detected, including adenovirus, bocavirus, coronavirus, metapneumovirus, paramyxovirus types I-IV, respiratory syncytial virus, and rhinovirus. At the same time, both before and during the COVID-19 pandemic, different influenza virus variants cocirculation (A/H1N1, A/H3N2, and type B) were discovered, with a predominance of viruses with the antigenic formula A/H1N1. The results of the study indicate the need for continuous monitoring of the viral pathogens spread, which will expand the existing knowledge of the viral etiology of respiratory diseases and highlight the importance of viruses in the respiratory infections occurrence.
Респираторные вирусные инфекции, являясь наиболее распространенными среди всех заболеваний человека, наносят огромный ущерб здоровью людей и экономике. Социркуляция разных вирусов и вариативность их соотношения от сезона к сезону осложняет подбор средств для профилактики и лечения. Кроме того, часто имеет место инфицирование вирусами с устойчивостью к специфическим препаратам. Проблема резистентности инфекционных агентов к лекарственным средствам на сегодняшний день является одной из главных задач, стоящих перед биологическими и медицинскими науками. Лекарственная устойчивость вирусов является результатом изменений их наследственных свойств и нередко связана с избыточным использованием препаратов. Вероятность появления устойчивых к препаратам штаммов вирусов нарастает с увеличением продолжительности лечения в клинической практике. Наряду с этим, более 30% резистентных штаммов обнаруживается у больных, никогда не принимавших этиотропные препараты. Поэтому важно выявить соотношение чувствительных и устойчивых штаммов в популяции, изучить механизмы возникновения устойчивости и возможные способы её преодоления. Вирусы гриппа, изолированные в Казахстане с 2015 г., проявляют чувствительность к препаратам на основе озельтамивира и широкий спектр восприимчивости к препаратам адамантанового ряда. Изучение чувствительности аборигенных вирусов к противовирусным препаратам предоставляет информацию для формирования рекомендаций по использованию лекарственных средств для лечения и профилактики гриппозной инфекции у населения. Рациональное использование и подбор лекарственных средств может позволить снизить экономические потери, связанные с временной нетрудоспособностью части населения в эпидемический период. Respiratory viral infections, being the most widespread among all diseases in humans, cause enormous damage to human health and the economy. The co-circulation of various viruses and the variability of their correlation from season to season complicate the selection of agents for the prevention and treatment. In addition, infection with viruses that are resistant to specific drugs occurs frequently. Drug resistance in infectious agents is one of the major challenges of our time facing the biological and medical sciences. Drug resistance among viruses is the outcome of changes in their hereditary properties and is often associated with excessive use of medicines. The likelihood of the emergence of drug-resistant strains increases with the treatment duration in clinical practice. At the same time, more than 30% of resistant strains are found in patients who have never taken etiotropic drugs. It is therefore important to reveal the correlation between sensitive and resistant strains in the population and to understand the mechanisms for the emergence of resistance and possible ways to overcome it. Influenza viruses isolated in Kazakhstan since 2015 reveal sensitivity to oseltamivir-based drugs and a wide range of susceptibility to adamantane drugs. Study of the sensitivity of native viruses to antiviral drugs provides information for the formation of recommendations for the use of drugs intended to treat and prevent influenza infection in the population. Rational use and selection of drugs can reduce economic losses associated with a temporary disability among a part of the population during the epidemic period.
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