A total of 25 boys and 20 girls aged 5-17 years with type I diabetes mellitus and disease durations of 2-10 years were studied. All had diabetic polyneuropathy. The microcirculation was studied by laser Doppler flowmetry. Treatment consisted of using a running impulse magnetic field. This method was found to be effective in diabetic polyneuropathy with the running field along the limb towards the periphery at a run velocity (field modulation frequency) being a multiple of the nerve fiber spike conduction velocity.

Childhood obesity is an urgent problem of pediatric endocrinology due to the widespread occurrence, the development of metabolic complications and their steady tracking into adulthood. The developed clinical guidelines are the main working tool of the practitioner. They briefly and structurally present the main information about the epidemiology and modern classification of obesity, methods of its diagnosis and treatment based on the principles of evidence-based medicine.

Objective:We report a male patient with ovotesticular disorder of sex development (OTDSD), resulting from structurally abnormal Y chromosome. Case report: A 3-year-old boy was admitted to the Surgical Pediatric Department for masculinizing reconstruction. He had a clitorophallus, bifi d scrotum, perineal hypospadias and bilateral impalpable gonads. Pelvic ultrasound and laparoscopy showed a uterus and two gonads with primary ovarian follicles. Chromosome analysis detected a mos 47,XX,mar/46,XX karyotype. Complex genetic evaluation revealed that the marker was Yp isochromosome. Surgical care included a feminizing genitoplasty and separation of the gonads with total excision of testicular tissue. Conclusions: The presented case emphasizes the importance of a systematic approach to the investigation and management of the patients with ovotesticular DSD. It also raises the important issue about gender reassignment in intersex individuals in mid-childhood.

Serum pseudocholinesterase activity in pregnant women was assayed spectrophotometrically using either propionylthiocholine or suxamethonium as substrate. All patients had a normal phenotype as indicated by normal dibucaine and fluoride numbers. However, the mean cholinesterase activity was lower than in the general population. There was a negative correlation between cholinesterase activity and the duration of neuromuscular blockade following suxamethonium, but no correlation was observed between the cholinesterase activity and the duration of block following atracurium.

No abstract

Abstract:Aspects of reactivation and remediation of impaired functions of the brain and of the inner organs regulatory systems are crucial to medical science. The study presents the technique of transcranial magnetic therapy (TMT) with extremely low frequency alternating magnetic field employed for balanced activation of central nervous system function. This study was aimed to assess the effectiveness of TMT in diseases caused by hypothalamic-pituitary dysfunction. Material and Methods -90 children aged 10-16 years with different diseases but with similar pathogenic patterns were enrolled in the study. Group 1 included 30 adolescent girls with menstrual irregularities. Group 2 included 30 children with nocturnal enuresis. Group 3 included 30 teenage boys with constitutional delay of growth and puberty. Medical histories were studied, clinical and laboratory evaluation was carried out. TMT stimulation was performed using the device "AMO-ATOS" (TRIMA LLC, Saratov, Russia).Results -Children in all the groups had high incidence of antenatal and perinatal pathologies recorded in their medical histories. Analysis of electroencephalograms (EEG) showed the prevalence of disorganized and flat EEG patterns -70% in all the children. Sympathicotonia being the symptom of autonomic nervous system dysfunction, prevailed in 60-80% of the children. The children in the three groups had hormonal imbalance. The treatment with TMT resulted in considerable improvement in hormonal balance and laboratory findings. Conclusion -ТМТ stimulation is effective in remediation of impaired functions of the brain and treatment of the diseases caused by hypothalamic-pituitary dysfunction.Keywords: hypothalamic-pituitary dysfunction, transcranial magnetic therapy, menstrual irregularities, neurogenic urinary bladder dysfunction, constitutional delay of growth and puberty Cite as Bolotova NV, Averianov AP, Timofeeva SV, Raigorodsky YM, Morova OL. Transcranial magnetic therapy is an effective strategy for remediating neuroendocrine pathology.

The paper deals with the prevalence and specific features of the metabolic syndrome (MS) in children with different forms of obesity and with the capacities of its correction. Ninety-eight children aged 9-17years, including 44 children with exogenous constitutional obesity and 54 with pubertal juvenile dyspituitarism, were examined. For the diagnosis of MS, clinical exami­nations methods were used. These included: estimation of the body mass index, circumferences of the waist and hips, their ra­tio, the levels of total cholesterol, triglycerides, coagulogram, fasting insulin, the routine glucose tolerance test, and fasting glucose/insulin ratio. The incidence of MS in obese children was 42.9%. A combination of 5 components of MS, such as in­sulin resistence, abdominal obesity, hyperlipidemia, hyperco- agulative changes, and aterial hypertension, was noted in 23.8% of the children and that of 4 and 3 (incomplete MS) components in different combinations was in 52.4 and 23.8%, respectively. The combined therapy low-calorie diet and metformin (Siofor, Berlin-Chemie) was used to correct the metabolic disturbances detected in 28 children aged above 13 years. The use of Siofor in children with MS, unlike dietary monotherapy, substantially improved the values of total cholesterol, fibrinogen, and blood pressure and normalized a response to glycemic load in most patients

A 46,XY ovotesticular disorder of sexual development is a rare variant of pathological gonadal differentiation. A 15-month-old patient had ambiguous external genitalia, no palpable gonads, and the 46,XY karyotype. The uterus was detected by imaging of the lesser pelvis. Gonads resided on the fallopian tubes and macroscopically resembled ovotestes: each gonad consisted of two compartments separated by a connective tissue interlayer. Histological examination showed that one gonadal portion consisted for ovarian tissue, was differentiated into the cortical and medullary matter, and contained primordial follicles with pronounced dystrophic changes. The remaining portions consisted of immature tubular epithelium with proliferative cellular changes. The decision about bringing up as a female with possible adaptation during puberty was justified in this case. The surgical approach was selected on the basis of histological examination and a decision on performing gonadectomy was made.