Search for effective and available methods of stimulation of regenerative processes is a priority task of restorative medicine. Of high interest is a kind of biostimulation that induces activation of metabolic and reparative processes in the whole organism. Aim. Generalization of the relevant literature data concerning possible mechanisms of biostimulation in transplantation of self tissues of an organism. The results of literature survey showed that there still remain many debatable questions concerning cellular and molecular mechanisms that underlie intermolecular interactions in the stage of regeneration. Stimulating effects of an autotransplant both in the zone of the transplant or in an organism in whole may be caused by mediators and signal molecules released in destruction of the autotransplant tissues and of its perifocal region, and also by bioactive substances produced by immune-competent and stem cells. Conclusion. Tissue transplants may be used as inductors of production of biologically active substances and activators of immune and/or stromal cells. The latter, in turn, are producers of a number of chemical mediators required for large-scale regeneration. Therefore, a promising method of stimulation of regenerative processes is transplantation of self tissue. This method is characterized by simplicity, effectiveness and availability which evokes special interest and requires further study.
The study is based on the study of 30 organ complexes from the human thoracic cavity, distributed into 5 age groups with 10-year interval, 6 observations in each group: 1st age group – 20–30 years, 2nd age group – 31–40 years, 3rd age group – 41–50 years, 4th age group – 51–60 years, 5th age group – 61–70 years. All medications were taken from people without heart and lung pathology at forensic autopsy according to the generally accepted method. Based on the results obtained, topographic features of lymph nodes location around the right main bronchus are given, which is of practical interest.
This article examines the legal issues related to voluntary vaccination against the novel coronavirus infection COVID-19. It is noted that usage of contract with regards to mandatory vaccinations against coronavirus is impossible, as from the legal perspective, signing a contract is voluntary. Therefore, it is necessary to issue the corresponding legislative act that would not only establish the responsibility, but also ensure right for protection of biological database. There is also a need to settle the matter pertaining to storage of the collected biomaterial, as well as monitoring of the process of testing mass vaccination. There are currently no legislative acts on this issue, which necessitates the development of normative legal acts thereof. The article reviews the legal issues related to voluntary vaccination against the novel coronavirus infection COVID-19. There yet multiple unresolved legal issues regarding the application of new vaccine, requirements for its transportation, and storage of biological materials. It is underlined that if a pedagogue, medical employee, or sales person are not vaccinated against coronavirus, the suspension of this category of citizens or refusal to hire is currently unlawful. This is substantiated by the fact that in order for vaccination against any infectious disease (including COVID-19) to be mandatory, it is essential to make amendments to not only the aforementioned legislative act, but also to the framework law of 11.11.2011 No. 323-FZ “On the Fundamentals of Protection of Public Health in the Russian Federation”. These legislative acts should ensure the rights of citizens for refusal of medical treatment overall, as well as refusal of preventive vaccinations in particular.
This article examines the scenario of game simulation “The City Started by You”. The game represents an information platform built on the basis of online game, where the players select a city they would like live in and the services they would like to use. The players are also given the opportunity to discuss and make management decisions regarding the development of their city. The game touches upon such questions as solidarity in society, meaning of paying taxes, value of local democracy, proactive budgeting, and implementation of direct online democracy. The game is aimed at the development of the skills for classification of the topical issues and separate delegated authority, liaising between the authorities and officials of the city’s self-governance and the residents, as well as engagement of city residents in urban management. The computer game not only calculates the consequences of the made by the student management decisions, but also takes into account the factors of the internal and external environment. It is noted that this game can be used as educational in schools and universities, as well as for increasing information transparency between the executive branches and municipal officials. The latter would require conducing educational online games within the framework of group classes with the municipal officials. The use of remote technologies built on the basis of game simulation “The City Started by You” allows to consider and analyze alternate solutions of topical issues, work out spatial development strategies, and form project thinking. Game simulator Constant improvements in the area of ensuring transparency of the local self-governance is essential for increasing public confidence in the local authorities, effective solution of topical issues, and successful conduct of the reforms.
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