BACKGROUND: In most countries, there is a rapid increase in the population of patients with type 2 Diabetes Mellitus (DM). Bone changes in postmenopausal women with type 2 DM are associated with increased bone mineral density (BMD). The study of metabolic processes in bone tissue in comorbid pathology in different ethnic groups is continuing. AIMS: To study the concentration of markers of bone remodeling and indicators of BMD in postmenopausal women with type 2 DM of the Buryat population. MATERIALS AND METHODS: Thirty-nine postmenopausal women with type 2 DM (22 Russian population and 17 Buryat population) were examined. The comparison group consisted of 42 postmenopausal women (21 Russian population and 21 - Buryat population). The study of BMD in the lumbar spine (L1-L4), the femoral neck (Neck), and the proximal femur (Total hip) was performed using dual-energy X-ray absorptiometry. Parameters of osteocalcin (OC), type 1 N-terminal procollagen propeptide (P1NP), C-terminal telopeptides of type I collagen (-Cross laps), 25(OH) vitamin D and ionized calcium were evaluated. RESULTS: The presented study revealed a simultaneous increase in osteosynthesis: ОС (p=0.048) and P1NP (p=0.016) and in the bone resorption marker -Cross laps (p=0.020) accompanied by the absence of changes in BMD in women with type 2 DM in the postmenopausal period of the Buryat population relative to women with type 2 DM in the postmenopausal state of the Russian population. A decrease in osteosynthesis parameters (ОC, p=0.021; P1NP, p=0.029) with an increase in BMD L1-L4 (p=0.024) and BMD Total hip (p=0.039) in postmenopausal women with type 2 DM of the Buryat population was found relative to the women of the Buryat population in comparison group. CONCLUSIONS: The state of bone tissue in postmenopausal women with type 2 DM of the Buryat population is characterized by the activation of bone remodeling processes.
There is a difference of bone tissue state of women belonging to various ethnic groups. We have conducted a study of bone tissue state among postmenopausal women of Buryat origin. Buryats are a main northern group of Mongolians, they are a core population of Siberia with a compact residence close to Lake Baikal. We have examined the associations between bone mineral density (BMD), trabecular bone score (TBS) and bone biomarkers in 17 postmenopausal women with T2D (59 years, diabetes duration 5.2 years, A1c <8.0%) and 21 postmenopausal women without diabetes (56 years). Collagen type 1 cross-linked C-telopeptide (CTX), 25-hydroxyvitamin D, ionized calcium (iCa), femoral neck BMD were similar between two groups. T2D postmenopausal women had lower osteocalcin (OC), procollagen type 1 N propeptide (P1NP), TBS and higher BMD total hip, BMD lumbar spine 1-4 (L1-L4) compared to the controls (Table). Total hip BMD in women with T2D was associated with body mass index (BMI). TBS was positively correlated with iCa. Twenty-five-hydroxyvitamin D was associated with lower OC, P1NP and CTX. Total hip BMD and BMD L1-L4 were positively correlated with BMI in women without diabetes. Femoral neck BMD was positively correlated with P1NP and inversely correlated with women’s age. T2D in Buryat women is associated with low levels of osteosynthesis markers, TBS and higher BMD. TBS was positively correlated only with iCa. Disclosure T. Bardymova: None. M. Mistiakov: None. M. Berezina: None. S. Tsyretorova: None. V. Velm: None.
ЦЕЛЬ: разработать способ оценки риска развития структурно-метаболических нарушений костной ткани у женщин, больных сахарным диабетом (СД) 2 типа.МАТЕРИАЛЫ И МЕТОДЫ: в исследование включено 73 женщины, больных СД 2 типа, без тяжелых коморбидных заболеваний и состояний из них 34 -с сохраненной функциональной активностью яичников, средний возраст 44,1±3,5 г., и 39 женщин -в постменопаузальном периоде, средний возраст 58,2±4,2 г. Группу сравнения составили 88 женщин без нарушений углеводного обмена, из них 46 женщин с сохраненной функциональной активностью яичников, средний возраст 44,0±3,8 г., и 42 женщины в постменопаузальном периоде, средний возраст 56,3±4,7 г. Изучали МПК поясничного отдела позвоночника, шейки бедра, проксимального отдела бедренной кости и трабекулярный костный индекс (ТКИ) методом двухэнергетической рентгеновской абсорбциометрии (аппарат Lunar Prodigy, General Electric, США). Дополнительно определяли показатели остеокальцина, С-концевых телопептидов коллагена I типа (β-Cross laps), N-терминального пропептида проколлагена 1 типа (P1NP), витамина 25(ОН) D, ионизированного кальция.РЕЗУЛЬТАТЫ: методом проведенного дискриминантного анализа полученных в исследовании результатов выявлены наиболее информативные признаки, свидетельствующие о ранних изменениях костной ткани у пациенток с СД 2 типа, а также рассчитаны величины коэффициентов F1,
Inflammatory processes during type 2 diabetes mellitus (T2D) and evolution of ST-elevation acute myocardial infarction (STEMI) are different in various ethnic groups. Buryats are the main northern group of Mongolians, they are a core population of Siberia. We have examined the associations between cytokines and high sensitivity C-reactive protein (hs-CRP) in 14 patients (36% males) with T2D and STEMI of Buryat ethnic group (60 years, diabetes duration 7.9 years, A1c 8.0%); in 21 Caucasian patients (48% males) with T2D and STEMI (60 years, diabetes duration 8.0 years, A1c 7.9%); in 13 patients (77% males, 59 years) with STEMI without T2D of Buryat ethnic group and 18 Caucasian patients (72% males, 61 years) with STEMI without T2D.Buryat patients with T2D and STEMI had higher hs-CRP and lower interleukin-8 (IL-8) and interleukin-10 (IL-10) compared to Buryat patients with STEMI without T2D. Caucasian patients with T2D and STEMI had higher hs-CRP and lower tumor necrosis factor alpha (TNF-α) compared to Caucasian patients with STEMI without T2D. Buryat patients with T2D and STEMI had lower interleukin-6 (IL-6), IL-8, IL-10 and hs-CRP compared to Caucasian patients with T2D and STEMI. We have determined decreased secretion of cytokines and hs-CRP in patients with T2D and STEMI of Buryat ethnic group compared to Caucasian patients. Disclosure T. Bardymova: None. K. Protasov: None. T. Belochvostikova: None. S. Tsyretorova: None. M. Mistiakov: None. O. Donirova: None. M. Berezina: None.
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