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Background: Diseases characterized by elevated blood pressure are the most frequently diagnosed pathology among socially significant diseases in the Russian Federation. According to clinical recommendations of the Russian Medical Society for Arterial Hypertension 2010-2019, the use of two and more component drugs improves the compliance of patients to treatment. The purpose of this study was a comparative analysis of preferences in the usage of combined antihypertensive drugs in ten regions of the Far Eastern Federal District (FSD). Materials and Methods: Intra-group analysis of data on the sale of antihypertensive drugs in pharmacy organizations (162 drugstores) for the period 2018 was carried out in the 10 regions of the FSD. The sample is uneven due to the difference in total number of drugstores in the regions. The sample was random. Pharmacies were in urban and rural areas. The total purchase of all defined daily doses of all antihypertensive drugs was taken as 100%. Then, fixed-dose combinations were selected. The share of each drug in the sales structure was then calculated. Kruskal-Wallis criterion was used for determining the differences in the structure of acquisition of drugs between the regions. The Spearman's rank correlation and factor analysis were used for determining the correlation between the drug's acquisition structure and the FSD region. Results: Two-component drugs are most in demand in the Amur region-15.2% and Zabaykalsky Krai-12.3%, and the lowest demand in the Sakhalin region-5.25% and Magadan region-6.5%. The largest sales indicators of three-component drugs were observed in the Zabaykalsky Krai-1.2% and the Republic of Buryatia-1.0%. The most acquired combinations were atenolol+chlorthalidone, valsartan+amlodipine, losartan+hydrochlorothiazide, perindopril/lisinopril/ramipril+amlodipine, perindopril+indapamide. Conclusion: Group leaders may vary depending on the region, which is due to the preferences of medical specialists. However, the differences are not significant, which proves the unity of approaches to combined drug therapy of arterial hypertension.
The objective data about traditional, interactive, and distance learning methods in the specialty «Pharmacy» their characteristics, advantages, and disadvantages are limited. To analyze the characteristics of various teaching methods at the Far Eastern State Medical University. Sociological survey of students (n = 267) majoring in «Pharmacy» of the Faculty of Pharmacy and Biomedicine (higher education), and of the Medico-Pharmaceutical College (secondary education). The most characteristic advantages of traditional teaching methods include the availability of information (2,6), the ability of the teacher to control the student (2,51), and the objectivity of assessments (2,52). The advantages of interactive methods include the objectivity of the teacher's assessments, the ability to demonstrate creativity (2,31) and thematic training (2,27). The advantages of distance learning methods include objectivity of the teacher's assessments (2,35), convenience, and accessibility of information (2,33). The highest scores for traditional teaching methods can be explained by their simplicity and accessibility. The benefits of interactive learning methods are underestimated by respondents, probably due to the need for systematic training, as well as the application of knowledge in a specific situation and creative problem solving. The main advantages of distance education technologies include convenience, and the availability of information since it is published in free access, as well as the objectivity of the assessment -due to the use of computer testing. Traditional learning methods have the greatest advantages. A rational combination of all teaching methods is necessary for realizing the convenience and creative approach to form communications.
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