The purpose of the study was to compare the values of acid base balance, electrolytic and hemodynamic parameters in newborns depending on the composition of intraoperative infusion therapy. The study was done in 60 newborns who were given Staerofundin ISO basic infusion (10 ml/kg/hour) in group I (n=31) and normal saline solution in group II (n=29) during a surgery.Results: following the surgery, no differences in pH values were observed between the groups, moderate metabolic disturbances were found. In Group II, levels of bicarbonates decreased from 22.2 to 20.5 (р=0.047). By the end of the surgery, normal electrolyte composition was found more frequently in group I (29%) as compared to group II (20%). Hypopotassemia (34.5% and 22.6%), hyperpotassemia (44.8% and 25.8%) and hyperchloremia (63% and 51.7%) were found more frequently in group II as compared to group I, respectively. To achieve the target level of blood pressure, the bolus was injected to 29% (n=9) of children from group I and 17.2% (n=5) of children from group II. Adrenergic agonists were used in 42% of children from group I and 27.6% of children from group II (р=0,038). There were no differences between the cumulative doses.Conclusion. Sterofundin and normal saline solution demonstrated equivalent values of effectiveness and produced similar effect on the values of acid base balance, electrolytic and hemodynamic parameters during the intraoperative period in newborns.
Intraoperative infusion in newborns and premature infants is a very important part of anesthesia, which affects the course and long-term results of the surgical treatment. The purpose of the infusion therapy in these children is to maintain normovolemia, adequate oxygen supply to tissues, normalization of the acid-base state, electrolyte balance and normoglycemia. In most cases, the maintenance of hemodynamics in newborns and premature infants requires the use of large amounts of crystalloid preparations, which in turn, due to their physical and chemical properties, lead to additional changes in the neurohumoral status of the child. Therefore, at the present stage of anesthesiology more and more works are devoted to the experience of using balanced solutions containing carriers of reserve alkalinity. The influence of such solutions on the electrolyte balance and acid-base state is evaluated. A separate issue is concerned with the intraoperative need for glucose in newborn infants, the dosing of glucose in anesthesia, and the percentage of glucose in the solutions used. Correction of all pathophysiological disorders inevitably occurring in the immature body of a newborn, especially a premature baby, is the most important factor for achieving the optimal therapeutic effect.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.