Effects of solid and liquid digestate for hydroponic baby leaf lettuce (Lactuca sativa L.) cultivation

Small interfering RNAs (siRNAs) with N -acetylgalactosamine (GalNAc) conjugation for improved liver uptake represent an emerging class of drugs to treat liver diseases. Understanding how pharmacokinetics and pharmacodynamics translate is pivotal for in vivo study design and human dose prediction. However, the literature is sparse on translational data for this modality, and pharmacokinetics in the liver is seldom measured. To overcome these difficulties, we collected time-course biomarker data for 11 GalNAc–siRNAs in various species and applied the kinetic-pharmacodynamic modeling approach to estimate the biophase (liver) half-life and the potency. Our analysis indicates that the biophase half-life is 0.6–3 weeks in mouse, 1–8 weeks in monkey, and 1.5–14 weeks in human. For individual siRNAs, the biophase half-life is 1–8 times longer in human than in mouse, and generally 1–3 times longer in human than in monkey. The analysis indicates that the siRNAs are more potent in human than in mouse and monkey.

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Crystalline O,O′-di-sec-butyl and O,O′-diethyl dithiophosphate platinum(II) complexes: Synthesis, 13C and 31P CP/MAS NMR, single crystal X-ray diffraction studies and thermal behaviour

Rodina

Иванов

Герасименко

et al. 2011

Polyhedron

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Synthesis and biological properties of pyrimidine 4′-fluoronucleosides and 4′-fluorouridine 5′-O-triphosphate

et al. 2010

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4'- Fluoro-2',3'-O-isopropylidenecytidine was synthesized via interaction of 5'-O-acetyl-4'-fluoro-2',3'-O-isopropylideneuridine with triazole and 4-chlorophenyl dichlorophosphate followed by ammonolysis. Treatment of 5'-O-acetyl-4'-fluoro-2',3'-O-isopropylidenecytidine with hydroxylamine resulted in 5'-O-acetyl-4'-fluoro-2',3'-O-isopropylidene-N(4)-hydroxycytidine. Subsequent removal of 2',3'-O-isopropylidene groups gave 5'-O-acetyl derivatives of 4'-fluorouridine, 4'-fluorocytidine and 4'-fluoro-N(4)-hydroxycytidine. 5'-O-Triphosphate of 4'-fluorouridine was obtained in three steps starting from 4'-fluoro-2',3'-O-isopropylideneuridine. The 4'-fluoro uridine 5'-O-triphospate was found to be an effective inhibitor of HCV RNA-dependent RNA polymerase, substrate for NTPase reaction, catalyzed by protein NS3 HCV (a rate of the analogue hydrolysis was similar to that of ATP) and an activator for helicase reaction (with an efficacy only three fold lower than that of ATP).

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Synthesis, structural and multinuclear natural abundance (13C, 31P, 195Pt) CP/MAS NMR studies of crystalline O,O′-dialkyldithiophosphate platinum(II) complexes

et al. 2008

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Crystalline cadmium dialkyl phosphorodithioate complexes: Synthesis and structural organization as probed by multinuclear 13C, 31P, and 113Cd CP/MAS NMR and single-crystal X-ray diffraction

Иванов

Лосева

Иванов

et al. 2007

Russ. J. Inorg. Chem.

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Effect of heterocyclic diimine ligands with donor and acceptor substituents on the spectroscopic and electrochemical properties of Au(III) complexes

et al. 2006

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Structure of crystalline bismuth(III) N,N-dipropyldithiocarbamate [Bi{S2CN(C3H7)2}3] according to 13C and 15N MAS NMR and X-ray diffraction analysis: Supramolecular self-organization and conformational isomerism

et al. 2014

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М. А. Иванов

Conformational isomerism of the binuclear N,N-pentamethylenedithiocarbamate cadmium(II) complex, [Cd2{S2CN(CH2)5}4] on multinuclear (15N,113Cd) CP/MAS NMR and single-crystal X-ray diffraction data

Cross-Species Translation of Biophase Half-Life and Potency of GalNAc-Conjugated siRNAs

Crystalline O,O′-di-sec-butyl and O,O′-diethyl dithiophosphate platinum(II) complexes: Synthesis, 13C and 31P CP/MAS NMR, single crystal X-ray diffraction studies and thermal behaviour

Synthesis and biological properties of pyrimidine 4′-fluoronucleosides and 4′-fluorouridine 5′-O-triphosphate

Synthesis, structural and multinuclear natural abundance (13C, 31P, 195Pt) CP/MAS NMR studies of crystalline O,O′-dialkyldithiophosphate platinum(II) complexes

Crystalline cadmium dialkyl phosphorodithioate complexes: Synthesis and structural organization as probed by multinuclear 13C, 31P, and 113Cd CP/MAS NMR and single-crystal X-ray diffraction

Effect of heterocyclic diimine ligands with donor and acceptor substituents on the spectroscopic and electrochemical properties of Au(III) complexes

Structure of crystalline bismuth(III) N,N-dipropyldithiocarbamate [Bi{S2CN(C3H7)2}3] according to 13C and 15N MAS NMR and X-ray diffraction analysis: Supramolecular self-organization and conformational isomerism

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