One of the urgent problems of medicine is the relationship between the main aspects of the quality of life and the cognitive abilities of primary school children. This problem also covers issues of pedagogy, psychology and social aspects of the life of the child population. The results of the study led to the conclusion about the main aspects of the quality of life (PedsQL 4.0 questionnaire), interrelated with the level of intellectual development (D. Wexlers method modified by A.Yu. Panasyuk (1973)) and academic performance (questionnaire) of first-graders at the beginning and at the end school year. The material was processed using the Mann Whitney U-test and the Wilcoxon W-test, for dependent and independent variables. A significant tendency towards a decrease in social and school functioning, psychosocial health, as well as emotional functioning at the end of the school year is shown, which indicates a decrease in adaptive mechanisms in younger students. The discrepancy between the level of IQ indicators and school performance of children was revealed. It was determined that children doing well at school had higher quality of life indicators. The most vulnerable for all the children studied was the psychosocial aspect of health. It was shown that in children with a high level of cognitive development, the emotional aspect of health decreased during the year, in primary school children with a low level of cognitive development, school functioning, and with an average, an increase in indicators of physical functioning. Given the identified features of the quality of life, which depend on the level of cognitive development, it is important to observe an individual approach to training, with the involvement of specialists from the psychological level.
Matrix metalloproteinases (MMP) play a special role in the pathogenesis of atopic dermatitis (AD). Therefore, the study of the features of genes responsible for the synthesis of MMP in children with AD is of great scientific and practical interest. Background. To study the role of polymorphic variants of matrix metalloproteinase genes (MMP 9 and MMP20) in the pathogenesis of AD in children. Materials and methods. Allelic variants of320A>C gene MMP20,837T>C gene MMP20, -8202 A>G gene MMP9 in children with AD were studied using the method of allele-specific polymerase chain reaction. The control group consisted of I and IIa the health groups patients of the corresponding sex and age. Results. The results of genetic studies showed that the incidence of alleles and genotypes in the polymorphisms 320A>C of the gene MMP20, 837T>C of the gene MMP20 in patients had no significant differences from the control group (p>0.05). It was established that the A/A-genotype of polymorphism -8202 A>G of the MMP9 gene, prevailed among children suffering from AD at a frequency of 69.2%, whereas in the group of healthy children the frequency of this genotype was 3 times lower (p=0.003). At the same time A/G-genotype (55.7%) was predominant in the control group, while G/G genotype was 2 times lower (21.3%). Thus the risk of AD increased by 7.55 times (OR=7.55 [95% Cl - 2.97-19.21; pG of the MMP9 gene, in particular the risk of developing of skin manifestations of allergy is increased by more than 7 times in A-allele homozygotes.
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