Ставропольский государственный медицинский университет, Российская Федерация Diabetes takes a leading place among the causes of blindness. One hundred three patients with type 1 diabetes mellitus (DM) aged from 18 to 45 years were examined with varying severity of visual disorders.Disease duration was from one year to 10 years. A neurophysiological examination was performed using visual evoked potentials on black-and-white (BW) and color (red-yellow (RY) and green-black (GBk))сhanging chess pattern(CCP).The results obtained in terms ofVEPindices made it possible to note that in all patients of the study group conduction disturbances were detected in the visual fibers of the analyzer, namely, an increase in the peak latency (PL) of P100 and a decrease in the amplitude of the wave (WA) N75-P100 with an earlier prevalence of disorders in the color-changing CCP relative toBW. The study has shown that in type 1 DMcolor vision as the most subtle structural element of the VAis primarily affected.
Aim. To determine the possibility of predicting the course and outcomes of aneurysmal subarachnoid hemorrhage (aSAH) by using the detection of autoantibody level to neurospecific proteins.
Methods. The autoantibody level to neurospecific proteins was detected in 65 people: 30 healthy volunteers and 35 with a confirmed diagnosis of aneurysmal subarachnoid hemorrhage. Autoantibodies to myelin basic protein (MBP), peripheral myelin, dopamine receptors, myosin, N-methyl-D-aspartate (NMDA) receptors and S100 protein detected by using an enzyme immunoassay. The severity of illness in dynamics was defined in all patients by using the following scales: Rivermead mobility index, HuntHess, Graeb and others. Statistical analysis was performed using Statistica 10.0, with the consistent use of descriptive statistics methods, the MannWhitney, KruskalWallis and Pearson tests, Spearman coefficient.
Results. At the first stage, neurospecific proteins characterized by a large increase in autoantibody titers were identified. Further, based on the data obtained, a statistically significant correlation between autoantibody titers to S100 protein (360.4340.35 g/ml, p 0.05), MBP (145.9112.43 g/ml, p 0.05), NMDA receptors (66.176.42 g/ml, p 0.05) and aSAH outcome was established.
Conclusion. The study revealed an increase in autoantibody level to neurospecific proteins in the blood plasma of patients, depending on the severity of subarachnoid hemorrhage and the development of delayed cerebral ischemia due to cerebral vasospasm; high antibodies titers to S100 protein in subarachnoid hemorrhage are associated with cerebral vasospasm and the development of secondary (delayed) ischemic changes in the brain.
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