We have shown that the H 2 O 2 concentration in exhaled breath condensate (EBC) in lung cancer patients increases significantly compared to the EBC of healthy people and revealed the correlation between the H 2 O 2 level in the EBC and amount of mtDNA damage in buccal mucosa cells. The H 2 O 2 hyper-production may trigger mitochondrial biogenesis, thereby resulting in an increase in mtDNA copy number. However, we did not observe a significant difference in the studied parameters between smokers and non-smokers. Overall, our data suggest that H 2 O 2 concentration in the EBC, the extent of mtDNA damage, and mtDNA copy number in buccal mucosa could be potential as an early diagnostic marker of lung cancer.
Background. A new strategy of breast cancer management is required for effective disease prevention and control. Immunotherapy is one of promising options.Objective: to evaluate the effect of immunoadjuvant polyoxidonium on pathmorphological changes in breast tumors.Materials and methods. The study was performed in 75 patients with breast cancer: 50 patients received polyoxidonium in a neoadjuvant regimen (main group), 25 patients did not receive polyoxidonium (control group). Polyoxidonium at a dose of 12 mg was administered intramuscularly 1 time per day on the days 1, 2, 3, 5 and 7 before surgery; on the day 8, radical mastectomy was performed in patients of both groups, followed by histological examination and determination of the grade of therapeutic pathomorphosis of the tumor.Results. The proportion of cases with grade I therapeutic pathomorphosis was 58 %, grade II therapeutic pathomorphosis – 6 %. Pathomorphosis in metastatic lymph nodes was observed in 22.7 % of cases.Conclusion. The anti-tumor effect of polyoxidonium was confirmed on the basis of the induction of pathomorphosis of the tumor tissue of breast cancer.
Актуальность Несмотря на, казалось бы, доступную для всех видов клинического исследования область поражения, досих пор остается проблема обнаружения рака груди у мужчин на ранних стадиях. Это связано со многими факторами,среди которых: недостаточная осведомленность мужского населения и врачей о данной патологии; неправильная интер-претация результатов маммографии и (или) УЗИ.Цель исследования Уточнить особенности лучевой диагностики рака молочной железы у мужчин.Материалы и методы ретроспективно проанализированы результаты рентгеновских (маммография, РКТ) 31 мужчины,страдающих раком молочной железы, проходивших обследование и лечение в Воронежском областном онкологическом дис-пансере в период с 2010 по 2016 гг.Результаты и осуждение выделены и обобщены различные признаки рака молочной железы у мужчин, полученные поданным маммографии и РКТ грудных клеток.Выводы: 1. Рентгенологические симптомы РМЖ у мужчин в целом аналогичны таковым у женщин. 2. Характерным дляРМЖ у мужчин является связь опухоли с кожей молочной железы, ареолы и соском. 3. При невозможности выполнениямаммографии для оценки характера и распространенности поражения молочной железы может быть использована РКТгрудной клетки. 4. Алгоритм лучевого обследования у мужчин с РМЖ должен включать маммографию, УЗИ молочныхжелез, РКТ грудной клетки, по возможности, ПЭТ\КТ с 18-ФДГ. 5. Осведомленность населения и врачей о возможностиРМЖ у мужчин может иметь большое значение для выявления заболевания на ранних стадиях и, как следствие, болееуспешного его лечения.Ключевые слова: рак, молочная железа мужчин, маммография
The aim of the study was to improve clinical outcomes of oral mucosa cancer in case of surgical treatment failure.Materials and methods. A clinical case of combined radiation treatment of a patient with oral floor mucosa cancer St III T3N1M0 was presented. Pathogistological diagnosis # xxxxxx was: highly differentiated squamous cell carcinoma. A treatment plan was developed. Chemoradiotherapy at the first stage included 3 courses of intra-arterial chemotherapy (Selective (superselective) embolization (chemoembolization) of tumor vessels in the basin of the left and right facial and left lingual arteries, cisplatin 150 mg, combined with a daily infusion of 5-fluorouracil 4000 mg), with an interval 21 day. Chemoradiotherapy at the second stage included volume modulated arc therapy (VMAT) on the area of the primary tumor (oral floor mucosa) and the regional metastasis pathways (total boost dose 60 Gy to the area of regional lymph flow, otal boost dose 50 Gy to the oral cavity). Chemoradiotherapy at stage 3 included interstitial radiation therapy. A single boost dose (SBD) for the primary focus was 3 Gy/per fraction, 2 times a day, with an interval of 6 hours until total boost dose reached 21 Gy, 7 fractions.Results. After treatment, a complete regression of the tumor was noted. No pathological accumulation of radiopharmaceuticals, features of the tumor process was detected on PET/CT 48 months after treatment.Conclusions. Chemoradiotherapy combined with brachytherapy can be considered as an equal alternative to surgical treatment of patients with oral mucosa cancer.
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