Today, cases of infection of various animal species with the new SARS-CoV-2 coronavirus have become increasingly common. This virus has been isolated from numerous representatives of the feline family, European mink, ferret, raccoon dog, domestic dog, a number of primates and a number of other animals. In most susceptible animals, infection with this virus is manifested by certain clinical symptoms, the intensity of which depends on the type and age of the animals, on the presence of concomitant diseases. The pathological process can end in death with the development of characteristic pathoanatomical and histological changes. According to the results of preliminary studies conducted in the Republic of Belarus, the circulation of SARS-CoV-2 was detected in domestic cats. All the animals had a history of contact with COVID-19-infected owners. The aim of this work was to determine the features of clinical and pathoanatomical manifestations, histological changes in domestic cats infected with SARS-CoV-2. The studies were conducted among various sex and age groups of domestic cats. In total, we conducted a study of 300 flushes from various sexes and ages and pedigreed, autopsy of 10 corpses. The work was carried out in the Vitebsk State Academy of Veterinary Medicine, the Vitebsk Regional Veterinary Laboratory, the RSPC "Epidemiology and Microbiology" in Minsk, in the Belarusian State Veterinary Center. The circulation of SARS-CoV-2 in animals was determined by polymerase chain reaction (RT - PCR). When dissecting the corpses of animals, the nature and severity of pathomorphological changes were taken into account, a pathoanatomical diagnosis was made, and macrophotography was performed in natural light. The main clinical symptoms of the disease in adult animals are depression, refusal to feed, cough, shortness of breath; in young animals, rhinitis, conjunctivitis, diarrhea are often observed. When dissecting dead animals, macro-changes and micro-changes in organs and tissues are noted, indicating the development of pathological processes, both in the acute course of the disease and in the chronic one. Thus, the conducted studies and the results obtained confirmed and supplemented the data of world researchers, made it possible to determine the leading clinical symptoms of the disease and pathoanatomical changes in the domestic cat when infected with SARS-CoV-2. The obtained data of histological changes allowed a deeper and more detailed assessment and study of the pathogenesis of the disease, which will contribute to a rational approach in choosing the means of therapy of this disease. Key words: cats, coronavirus, SARS-CoV-2, clinical symptoms, pathoanatomical changes, histological examination.
The aim of this study is to evaluate the possible protective effect of (toxicom) 5g\kg of ration against the toxic effects of mixed mycotoxins in growing broiler chickens .Total of 75 chicks ,one week old, are divided into 5 treated groups, 15 birds for each. The first group (G1) fed a contaminated ration with mycotoxin and supplemented with toxicom 5g/kg of ration and vaccinated with Infectious Bursal Disease (IBD) vaccine at 15 and 22 days of age. The second group (G2) is fed a ration contaminated with mycotoxin and vaccinated with IBD vaccine at 15 and 22 days of age and not supplemented with toxicom. The third group (G3)is fed a commercial broiler ration and vaccinated with IBD vaccine at 15 and 22 days of age . The fourth group (G4 ) is only fed a contaminated ration with mycotoxins. The fifth group (G5) is fed a commercial broiler ration as a control group. The mycotoxins in diet is analyzed by ELISA and the level is as follows : Aflatoxin B1 0.001 mg/kg ,Dezoxivalenol 1.24 mg/kg ,Zearalenon 0.068 mg/kg ,Ochratoxin 0.005 mg/kg ,T2 toxin 0.09 mg/kg ,Fuminisen B1 0.2 mg/kg. Results showed that toxicom significantly (P<0.05) protect chicken body weight, severity of clinical signs, morbidity and mortality rate. It is concluded which produced in Vitebsk State Academy of Veterinary Medicine is protect chicken that this preparation is protect chicken bioavailability parameters in comparison with the other groups and is recommended to use it as antitoxic material Republic of Belarus.
Under conditions of egg and poultry farming noninfectious diseases are widespread and cause significant economic damage. These diseases can be caused by a variety of etiological factors: the deficiency of the necessary chemical elements, substances or their combination, excessive amount of certain classes of organic substances in feed. Diseases of complex etiology are also recorded, which arise from a combination of unfavorable factors and anatomical and physiological properties of individual bird crosses. Under the influence of unfavorable factors in various organ systems, pathological processes of various nature (dystrophic, necrotic, inflammatory) arise. In this case, the symptoms and pathological changes can be either similar or poorly visible macroscopically. In this regard, the results of histological examination of organs and tissues play an important role in making a presumptive diagnosis. The article introduces the original results of researches on pathomorphological diagnosis of the most widespread diseases in industrial poultry farming of noninfectious etiology: chronic feed borne toxicoses (including mycotoxicoses), hypovitaminosis A, hyposelenosis, amyloidosis, necrosis of the femoral head. The results of examination of spontaneous material stuff. The findings are formulated in the form of histological diagnoses. The attention is focused on the main (pathognomonical) signs of a great value for differential diagnostics of this group of diseases. Various variants of pathomorphological course of the diseases running both in a classical way, and in the form of a pathomorphosis (the variated pathoanatomical and histological lesions against application of vaccines and antibiotics) are considered.
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