The production and properties of silver-containing products currently attract increasing attention due to the unique properties of silver. Specific properties of silver are considerably amplified when it is dispersed to the form of nanosized particles. Silver nanoparticles are several times more active than its other forms and many antibiotic and biocidal products. At the same time nanoparticles can more easily penetrate the protective barriers of living organisms and get directly into their tissues and organs. To be assured of safety of silver nanoproducts for human health and environment, it is necessary to study the influence of silver nanoparticles on the physiology of living organisms. This paper presents experimental data on effect of two nanosilver preparations (poviargol and argovit) on laboratory mice. Investigated preparations were characterized by transmission electron microscopy. It was established that morphological express control of peripheral blood and biochemical analysis of blood serum of living organisms can serve for purposes of primary monitoring of the pathological conditions caused by silver nanoparticles.
Recently the number of materials and goods produced by nanotechnology has been growing rapidly, leading to an increased penetration of nanoparticles into biosystems. To assess the risks associated with the production and circulation of nanoproducts should be developed methods for the rapid diagnostics of nanopathology. In this work, it has been experimentally shown that the introduction of metal oxides nanoparticles (TiO2, ZnO, Al2O3, CeO2) to laboratory mice leads to changes some profiles of specific hematological and biochemical blood parameters. Therefore for the purpose of early detection of symptoms of intoxication as benchmarks of the influence of metal oxide nanoparticles on living organisms can recommend express monitoring of peripheral blood (red blood parameters) and biochemical parameters of blood serum (activity of aminotransferases and indicators of nitrogen metabolism). The chosen indicators of blood can serve as diagnostic biomarkers in the development of rapid tests of primary monitoring of the impact of metal oxide nanoparticles on biological systems.
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