Objective: to estimate changes of uveitis activity using BOS24 (Behсet's disease Ocular attack Score 24) during antiinflammatory and immunosuppressive therapy in patients with Behcet's disease (BD).Subjects and methods. 103 (75.6%) of the 138 patients with BD fulfilled the 1990 International Study Group for Behсet's Disease (ISGBD) criteria had eye lesions; 55 (53.4%) of the 103 patients had an exacerbation of uveitis. 55 patients with an exacerbation of uveitis were found to have active inflammation in 94 eyes. The activity of uveitis was monitored during anti-inflammatory and immunosuppressive therapy, by using BOS24 that consists of 6 parameters with maximal possible value 24.Results and discussion. The mean BOS24 for 94 eyes with active uveitis at baseline was 9.33±0.91. The most pronounced inflammatory changes were found in the posterior chamber of the eye, mainly in the area of the peripheral retina, rarely in the area of the fovea and in the optic disc. All the patients with an exacerbation of uveitis received systemic therapy with glucocorticoids, cyclosporine and/or azathioprine. After 8.92±3.47 months of treatment, the mean BOS2 decreased significantly (p < 0.001) to 2.20±1.02. The most substantial positive changes were noted in the anterior chamber of the eye (p = 0.03), vitreous humor (p < 0.01), and peripheral retina (p < 0.001).Conclusion. BOS24 is a reliable tool to quantify uveitis activity in patients with BD and its dynamics during antiinflammatory and immunosuppressive therapy.
Behсet's disease (BD) is systemic vasculitis with multiorgan failure. According to the 1990 International Study Group for Behсet's disease (ISGBD) criteria, the main manifestations of the disease include recurrent mouth and genital ulcers; skin and eye lesions. Inflammatory diseases of the eye are diagnosed in 50–70% of patients with BD. Our described case illustrates the late diagnosis of BD in a 13-year-old girl, which led to severe eye disease (significantly decreased visual acuity of the left eye) 2 years after disease onset. The lesion of ocular posterior segments is the pathognomonic sign of BD. This symptom concurrent with other major manifestations of BD (skin and genital lesions) and the ethnicity of the patient (a resident of Dagestan, the region through which there was the Great Silk Road) should have promoted the earlier diagnosis of the disease.
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