The aim of the study was to evaluate the associations between the polymorphism rs8099917 IL-28β and changing of HIV viral load and the effectiveness of high active antiretroviral therapy during the treatment of chronic hepatitis C in HIV-infected patients. 80 HIV/HCV-infected patients were recruited in the study. Antiviral therapy was performed with pegylated interferon-α and ribavirin combined with concomitant HIV therapy. Polymerase chain method was used for the gene polymorphism IL 28b (rs8099917) and HIV viral load estimation. More than half (56.25%) patients treated with combined therapy showed a significant decrease in CD4 T-lymphocytes in TG-and TT-genotype groups. Furthermore, viral load of HIV RNA significantly declined in the group with TT genotype during the treatment. It was concluded that rs8099917 polymorphism of the gene IL-28β affects the dynamics of the HIV RNA viral load in HIVinfected patients receiving concomitant therapy for treatment of viral hepatitis C. Herewith, rs8099917 polymorphism combined with other factors can be used as a predictor of high active antiretroviral therapy effectiveness.
Abstract. The aim of the study was to evaluate the role of immune status and IFN gene polymorphism in the prediction of the efficacy of chronic hepatitis C antiviral therapy in HIV-infected patients. Eighty HIV-infected patients with hepatitis C were recruited. Antiviral therapy included pegylated interferon-α and ribavirin. Flow cytometry was used to test the immune status; polymerase chain reaction method was used for the IFN gene polymorphisms determination. It was found the significant differences in the immune status and allelic variants combinations of the genes responsible for the formation of an adequate immune and antiviral responses in groups of patients with different response to treatment of hepatitis C. Herewith the effectiveness of hepatitis C treatment in HIV-infected patients is associated with the activation of T-cell immunity. Polymorphisms of interferon gene with other prognostic factors, make it possible to better define the disease prognosis and the treatment efficacy.
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