Effects of extracellular proteases of Aspergillus ochraceus and Aspergillus terreus on plasma hemostasis proteins, consist of initiating the activation of prothrombin complex proteins, was detected. Was discovered, that A. ochraceus proteases have a direct influence on protein C and coagulation factor X, and A. terreus proteases causes their activation indirectly through kallikrein system stimulation. The ability of extracellular proteases of micromycetes activate prekallikrein in human blood plasma on the example of A. terreus was first demonstrated.
HighlightsMost of micromycetes are produced proteolytic enzymes which can affect human hemostasis proteins.For determination of such activity special chromogenic peptide substrates are used.Proteases secretion by micromycetes depends on medium composition.
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