Aims  The aim of this study was to determine the contemporary use of reperfusion therapy in the European Society of Cardiology (ESC) member and affiliated countries and adherence to ESC clinical practice guidelines in patients with ST-elevation myocardial infarction (STEMI). Methods and results  Prospective cohort (EURObservational Research Programme STEMI Registry) of hospitalized STEMI patients with symptom onset <24 h in 196 centres across 29 countries. A total of 11 462 patients were enrolled, for whom primary percutaneous coronary intervention (PCI) (total cohort frequency: 72.2%, country frequency range 0–100%), fibrinolysis (18.8%; 0–100%), and no reperfusion therapy (9.0%; 0–75%) were performed. Corresponding in-hospital mortality rates from any cause were 3.1%, 4.4%, and 14.1% and overall mortality was 4.4% (country range 2.5–5.9%). Achievement of quality indicators for reperfusion was reported for 92.7% (region range 84.8–97.5%) for the performance of reperfusion therapy of all patients with STEMI <12 h and 54.4% (region range 37.1–70.1%) for timely reperfusion. Conclusions  The use of reperfusion therapy for STEMI in the ESC member and affiliated countries was high. Primary PCI was the most frequently used treatment and associated total in-hospital mortality was below 5%. However, there was geographic variation in the use of primary PCI, which was associated with differences in in-hospital mortality.

Background. The International Society of Hypertension and World Hypertensive League therefore joined forces to organize a concerted global effort by expanding World Hypertension Day to May Measurement Month 2017 (MMM17). The campaign was aimed to improve hypertension awareness and blood pressure control in participants with hypertension. Russian Society of Cardiology supported initiative — blood pressure measurement was performed in 11 Russian cities.Objective. The aim of our study was to estimate Russian population awareness about blood pressure in terms of campaign MMM17.Design and methods. During May 2017 we screened 1532 participants in 11 Russian cities: St Petersburg (119 participants), Moscow (102), Belgorod (28), Bryansk (405), Kemerovo (142), Krasnoyarsk (154), Samara (67), Saratov (59), Stavropol (269), Ulyanovsk (50), Surgut (137). All subjects participated voluntarily. Inclusion criteria was age age older than 18 years old. Blood pressure (BP) was measured three times with automated and manual sphygmomanometers. Questionnaire regarding diabetes mellitus, cardiovascular diseases, smoking and alcohol intake was filled in. Respondents provided information about weight and height.Results. We examined 1532 participants aged 39,3 ± 18,7 years (from 18 to 90 years old), among them 509 (33,2 %) males and 1023 (66,8 %) females. All participants were divided into 3 groups according to the date of the last BP measurement: group 1 — BP has never been checked before (n = 188, 12,3 %), group 2 — less than one year ago (n = 630, 41,1 %), group 3 — more than one year ago (n = 714, 46,6 %).Conclusions. About half of Russian participants checked blood pressure last time more than one year ago. Insufficient awareness, low compliance to antihypertensive medication and poor blood pressure control were found in Russian population independently of gender and age in both primary and secondary prevention.

Международное общество по артериальной гипертензии и Мировая антигипертензивная лига организовали скрининговое исследование по измерению артериального давления (АД) под названием MMM19 -MAY MEASUREMENT MONTH 2019 для улучшения выявления повышенного АД и оценки контроля АД у пациентов с артериальной гипертензией (АГ). Цель. Определить приверженность к лечению российского населения по результатам скрининга АГ в рамках международной акции МММ19. Материал и методы. В течение мая 2019г в скрининге приняли участие 5394 человека из 21 региона России. Участие в акции было добровольным без ограничения по полу, возраст старше 18 лет. Во время скрининга трехкратно измерялось АД с помощью автоматических и механических тонометров, заполнялся опросник о наличии сахарного диабета, сердечно-сосудистых осложнений в анамнезе, курении и употреблении алкоголя. Также получена информация о дате последнего контроля АД и приеме статинов, ацетилсалициловой кислоты и антигипертензивных препаратов. Информация о росте и массе тела была получена со слов респондентов. Результаты. В анализ были включены данные 5274 пациентов в возрасте от 18 до 96 лет, из них 1834 мужчин (34,8%). Медиана возраста -25 лет, квартили -20 и 49 лет. Пропорция пациентов с АГ по результатам МММ19 в российской выборке составила 31,9%, а при исключении участников младше 25 лет -51,5%. Пациенты с АГ старше 25 лет принимают антигипертензивную терапию (АГТ) в 73,6%, при этом 38,6% пропускают прием препаратов, а достигают целевого уровня АД <130/80 мм рт.ст. только 11,8% мужчин и 17,2% женщин. Даже при использовании 4-5 антигипертензивных препаратов, только 20-30% участников акции достигали целевого уровня АД. Заключение. По результатам скрининга МММ19 в России лишь треть пациентов высокого риска измеряли АД в течение последних 12 мес., наблюдается низкая приверженность к приему АГТ и недостаточный контроль АГ. Более склонны к регулярному приему гипотензивных средств пациенты с АГ, имеющие в анамнезе сердечно-сосудистые осложнения.Ключевые слова: скрининг, артериальная гипертензия, артериальное давление, приверженность, осведомленность. Отношения и деятельность: нет.

Actuality.Impaired kidney function adversely influences both immediate and remote prognosis for patients with chronic heart failure (CHF). However, early detection and prediction of acute kidney injury (AKI) are understudied.The aimof study was to investigate hypoxia-inducible factor 1 (HIF-1) as a biomarker for early diagnosis of AKI and determining prognosis in patients with acute decompensated CHF (ADCHF).Materials and methods:84 patients admitted for ADCHF (18 women; mean age, 61.4±7.1) were evaluated. ADCHF was diagnosed in accordance with SEHF guidelines for diagnosis and treatment of chronic heart failure (RCS, 2016). AKI was diagnosed according to KDIGO criteria (2012). HIF-1, N-terminal pro B-type natriuretic peptide (NТ-proBNP), and erythropoietin were measured in blood serum. The follow-up period lasted for 12 months.Results:AKI was diagnosed in 27 (32.1 %) patients. Level of HIF-1 was 1.27±0.63 ng / ml; NТ-proBNP – 2469.6 (interquartile range (IQR), 1312.2; 3300.0) pg / ml; eryhthropoietin – 56.0 mIU / ml (IQR, 13.2; 68.1). No correlation was found between HIF-1 and glomerular filtration rate, NТ-proBNP, or erythropoietin. Differences in biomarker levels were not observed between patients with and without AKI; however, HIF-1 was higher in the group of deceased patients than in the group of survived patients (1.64±0.9 vs. 1.17±0.44 ng / ml, р=0.004), which was not observed for NТ-proBNP and erythropoietin.Conclusion.AKI was observed in every third patient with ADCHF. In ADCHF, HIF-1 was not correlated with the kidney function; however, a relationship was found between the HIF-1 level and prediction for patients with CHF.

No abstract

Engineering and geological surveys are summative concepts, the essence of which is to conduct a study of the geological properties of the soil on the territory of the construction site. The main goal is to obtain all the necessary materials to fully justify the possibility of designing and building any object on the selected territory. This study describes engineering and geological surveys of soil properties for the preparation of project documentation for the construction of an apartment building at the address Kirov region, Vyatskopolyansky district, village. Krasnaya Polyana, Druzhba str., 1. Statistical processing of physical characteristics of the studied soils, as well as indicators of physical and mechanical properties of soils are presented.

No abstract

Repetitive quarantines and social restrictions during the coronavirus disease 2019 (COVID-19) pandemic have negatively affected the population health in general, and the control of hypertension (HTN) in particular.Aim. To evaluate the control of HTN in the Russian population during the COVID-19 period based on the results of screening for HTN May Measurement Month 2021 (MMM2021).Material and methods. During May-August 2021, 2491 participants from 11 Russian regions took part in the screening. Participation was voluntary without restrictions on sex. All participants were over 18 years of age. During the screening, blood pressure (BP) was measured three times using automatic and mechanical BP monitors. In addition, a questionnaire was filled out on behavioral risk factors, comorbidities and therapy. HTN was diagnosed with systolic BP ≥140 mmHg and/ or diastolic blood pressure ≥90 mmHg and/or taking antihypertensive therapy. The questionnaire included questions about prior COVID-19, vaccinations and their impact on the intake of antihypertensive drugs.Results. The analysis included data from 2461 respondents aged 18 to 92, of which 963 were men (39,1%). The proportion of hypertensive patients was 41,0%, while among them 59,0% took antihypertensives and 30,9% were effectively treated. In comparison with pre-pandemic period according to MMM2018-2019, the higher proportion of HTN patients in the Russian sample was revealed during MMM2021 (41,0% vs 31,3%, p<0,001) with a comparable proportion of patients receiving antihypertensive therapy (60,7% vs 59,0%, p=0,05) and treatment efficacy (28,7% vs 30,9%, p=0,36). Monotherapy was received in 44,7% of cases, while dual and triple combination therapy — in 30,9% and 14,1%, respectively. The majority of respondents (~90%) did not adjust their antihypertensive therapy during the COVID-19 pandemic.Conclusion. According to HTN screening in Russia, there is persistent ineffective control of HTN, which may be due to both the worsening pattern of behavioral risk factors, limited access to healthcare during COVID-19, and the inertia of physicians and low adherence of patients due to the asymptomatic HTN course in the majority.