The metabolic cardiovascular syndrome (MS) is a common cluster of metabolic abnormalities (abdominal obesity, hypertension, dyslipidemia and carbohydrate metabolism disorders) that are related to insulin resistance and hyperinsulinemia and are associated with accelerated atherogenesis. Insulin excess is known to promote the development of the whole metabolic cascade. Recently it has been shown that the inflammatory and hemostatic abnormalities, immunological disorders, endothelial dysfunction, hyperhomocysteinemia and hyperuricemia are also important features of MS. Despite the numerous studies of MS its underlying cause is still not established. The dysfunction of visceral adipocytes (adiposopathy) might be genetically determined, and is considered nowadays as the main factor contributing to the development of the MS. Understanding the underlying mechanisms is of particular interest for prevention and target therapy of all the components of MS.
Optimizing treatments for type 2 diabetes mellitus (T2DM) remains an urgent issue. In addition to T2DM treatment strategies, such as glycaemic goals (glucose and glycated haemoglobin ? HbА1c) among different patient populations, the influence of glycaemic variability (GV) on the prognosis of patients with T2DM is also important. According to recent data, GV is associated with cardiovascular complications arising from T2DM. However, although the influence of GV on the development of vascular complications arising from diabetes and underlying mechanisms has been extensively investigated, few studies have investigated the effects of different glucose-lowering medications on GV, and there are even fewer reviews of this topic. This type of analysis is highly relevant, particularly because new classes of antidiabetic medications with potent glucose-dependent insulinotropic effects have been developed. These include groups of drugs that mimic or enhance incretin activity, such as glucagon-like peptide (GLP)-1 analogues/mimetics and dipeptidyl peptidase (DPP)-4 inhibitors. A glucose-dependent mechanism suggests that these groups of antidiabetic medications have beneficial effects on GV. Thus, the current study focusses on the comparative analysis of drugs based on their incretin effects (GLP-1 analogues/mimetics and DPP-4 inhibitors) and оther antidiabetic medications with regard to GV in the patients with T2DM.
The dynamics of the memory policy aimed at forming in the historical memory of the readership of the Siberian Lights Magazine of the 1920s-1940s ideas about the historical past and traditional culture of Altai people is traced in the article. The relevance of the study is due to the growing attention to the features of historical knowledge in the public space, its structuring, the means of conceptual interpretation and the use in the processes of political self-regulation of society at various stages of development. The novelty of the research is seen in the fact that the history of the state policy of memory in relation to the past of Gorny Altai in its substantive and procedural aspects has not yet become the subject of independent scientific research. The contexts and conditions of creating journal representations of the historical past of Gorny Altai are revealed. The list of the authors covering this topic is characterized, as well as the factors that influenced the creation of journal representations of the history of the Altai people. The stages of this representation are established and characterized. It is shown how the memory policy techniques used by the authors of this journal at different stages changed. It is proved that at the stage of the 1920s, the Siberian Lights served as a platform for polemics of historians and subjects of regional politics, relatively independent in relation to the central government. At the second stage of the 1930s - 1940s, the authors of the journal were included, first of all, in the process of implementing the policy of memory of the central authorities.
The purpose of this article is to generalize the dynamics of developing politics of memory, which was reflected in the processes of socio-political self-regulation of the Siberian region during the XX in the early XXI centuries. The study solves the problem of identifying the basic institutionalized forms and methods of using historical symbols within the framework of public commemorative practices and typical historical narratives, being established in Siberia in the XX beginning of the XXI centuries. The tasks also include identifying the stages of history of diverse manifestations of politics of memory in the memorial culture of Siberia in this period. The relevance of this article is due to the need of studying the meaning and methods of using historical symbols and commemorations within the framework of the politics of memory in order to form a critical, scientifically based position in relation to it. The study was implemented within the framework of the Memory Studies problem field and relies on interdisciplinary, sociocultural and socio-constructivist approaches. Comparative, diachronic, and systemic genetic methods there were used. For the first time the authors of the project intend to consider the politics of memory in relation to Siberia as a system that has gradually been formed and transformed depending on various conditions and factors. The scientific significance of the project is that the politics of memory implemented in the region by means of historical symbols and commemorative practices will be studied as a complex sociocultural phenomenon of regulating social consciousness of the regional society. As a result of the project implementation, the dynamics of using historical symbols and commemorations by various actors of regional politics in the sphere of building relations with central authorities and internal regional socio-political self-regulation processes. The authors define the stages of history of diverse manifestations of the memory policy in the memorial culture of Siberia. The Siberian macro-region, in spite of certain ethnocultural features in the areas where local peoples are densely populated, has emerged as one of the most Russian-oriented in its culture and dominant socio-political identity. And the basis of this result was the aggregate symbolic self-regulation of the Siberian society, which includes the dialectically complementary national and regional levels of memory policy.
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