In the clinic of the Volga Research Medical University on the basis of Nizhny Novgorod Regional Children’s Clinical Hospital” and “Children’s City Clinical Hospital № 1” from 2014 to 2018 82 newborns including 53 boys (65%) and 29 girls (35%) at the various stages of necrotizing enterocolitis were observed. There were 15 full-term infants (18%), and 67 premature newborns (82%). Symptoms of the disease were manifested in terms from 1 day to 25 days of life. During hospitalization, children were examined by neonatologists and hospital surgeons with the following by instrumental examinations (radiography, ultrasound). The severity of the condition and severity of the process were determined accordingly to the classification by to M.J. Bell (1978). The correlation between the clinical and epidemiological characteristics of newborns and the development of the pathological process was studied using the coefficient of conjugation of characters (φ), on the Wilcoxon, Van der Warden criteria and the sign criterion. Using mathematical analysis, conditionally “weak”, “medium” and “strong” risk factors for the development of NEC are identified. When assessing the occurrence of predictors in different stages of the disease, somatic diseases of the mother, chronic fetal hypoxia, fetal infections (IUI), chronic placental insufficiency (HFPN), weakness of labor, a body weight of the child <1500g were noted to be most often detected
Aim of the study: to discuss available information on vaccination of pregnant and breastfeeding women against COVID-19. Pregnant women with SARS-CoV-2 infection are at high risk of developing severe COVID-19 and adverse outcomes due to increased rates of preterm birth, caesarean section, and neonatal admissions to the intensive care unit. Concomitant chronic diseases increase the number of maternal and fetal complications. Taking into account the passive immunization of the newborn by transplacental transfer of maternal protective antibodies into the fetus and newborn blood circulation and then through breast milk, the role of vaccination in pregnant and breastfeeding women increases. Conclusions: after an individual risk-benefit assessment, COVID-19 vaccine should be recommended for pregnant and breastfeeding women.
The article presents a unique clinical observation of adrenocortical cancer (ACC) in a newborn baby, whose mother suffered from a recurrent form of maxillary fibrosarcoma and had a burdened obstetric and gynecological history, but was not examined by a geneticist. Complications of ACC in the presented patient were secondary hypertrophic cardiomyopathy with obstruction of the exit paths of both ventricles, Itsenko– Cushing syndrome. Despite the surgical treatment carried out according to vital indications (tumoradinectomy on the right with hormonal support with a Solu-Cortef), the child died during the progression of multiple organ failure and sepsis.
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