Коллагеновые волокна играют существенную роль в формировании связочного аппарата тазового дна. Однако, проведенные ранее исследования не дают точного ответа о роли полиморфных вариантов генов коллагена в дисфункции тазового дна. Целью настоящего исследования было определить ассоциацию однонуклеотидных полиморфизмов rs1800012 гена COL1A1, rs1800255 и rs1801184 гена COL3A1, rs2236479 гена COL18A1 и их сочетаний c пролапсом тазовых органов (ПТО) и стрессовым недержанием мочи (НМ). Группу исследования составили 150 пациенток с ПТО и/или НМ. В группу контроля вошли 100 пациенток без тазовой дисфункции. Пациентки были сопоставимы по возрасту и внешним факторам риска. Ассоциаций между полиморфизмами rs1800012 гена COL1A1, rs1800255 и rs1801184 гена COL3A1, rs2236479 гена COL18A1 и тазовой дисфункцией выявлено не было.
Collagen fibers play a significant role in the formation of the ligamentous apparatus of the pelvic floor. However, previous studies do not give an exact answer about the role of polymorphic variants of collagen genes on pelvic floor dysfunction. The aim of this study was to determine the association of single nucleotide polymorphisms rs1800012 of the COL1A1 gene, rs1800255 and rs1801184 of the COL3A1 gene, rs2236479 of the COL18A1 gene and their combinations with pelvic organ prolapse (POP) and stress urinary incontinence (SUI). The study group consisted of 150 patients with POP and/or SUI. The control group included 100 patients without pelvic dysfunction. Patients were comparable in age and external risk factors.All patients received a buccal epithelium for analysis. Sequencing was carried out by the Sanger method. Association between the rs1800012 polymorphisms of the COL1A1 gene, rs1800255 and rs1801184 of the COL3A1 gene, rs2236479 of the COL18A1 gene and pelvic dysfunction were not detected.
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