The aim of the work was to study the effect of the complex compound of nicotine acid with antihypoxic activity under the code πQ-1043 on the function of the central nervous system. The experiments were performed on male mice of the SHR line. Influence of the compound on the function of the central nervous system was evaluated in the tests “open field”, conditioned-defense reflex of avoidance and corazole seizures. It was found that the compound πQ-1043 at a dose of 25 mg/kg increases emotional reactivity and reduces the coefficient of mobility of mice in the “open field” test, increases the latent time of the conditionally defensive reflex of avoidance, inhibits the development of seizures and increases the life expectancy of animals after administration of corazole. Such changes in the studied parameters indicate that the compound πQ-1043 has a depressing effect on the central nervous system function. It is assumed that the identified effect may be one of the components in the mechanism of antihypoxic action of the compound.
The aim of the work was to study the antihypoxic properties of a number of complex zinc-containing compounds of nicotinic acid under the code πQ. The experiments were performed on male mice of the SHR line. Antihypoxic properties of compounds were studied on 4 models of acute hypoxia (hypoxia with hypercapnia, hypobaric, hemic, and histotoxic). It was found that the compound πQ-1043 in the dose spectrum of 10-100 mg/kg effectively increases the life expectancy of animals in all models of acute hypoxia. The compound πQ-1043 at a dose of 25 mg/kg reduces the oxygen consumption and rectal temperature of animals, which can be a key factor in its anti-hypoxic action. The compound does not change glycolytic carbohydrate metabolism in animals under normal conditions, but corrects these changes in acute hypoxia. Substance πQ-1043 maintains a high content in the blood of erythrocytes and hemoglobin under hypoxic conditions. The lethal dose 50 of the compound πQ-1043 applies to moderately toxic chemicals. It is assumed that the complex zinc-containing derivative of nicotinic acid πQ-1043 is a promising compound for the development of an effective drug for the correction of hypoxic states of different genesis.
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