In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabeculae and in preventing the occurrence of these microfractures, as well as increasing quality of experimental fractures healing.
The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them.
In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed, that in rats after ovariectomy the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabecules and in preventing the occurrence of these micro-fractures, as well as increasing quality of experimental fractures healing.
В статье аргументировано обоснование применения нового малотравматичного метода хирургического лечения переломов шейки бедренной кости. Метод основан на применении нового упруго-напряженного спицевинтового фик-сатора, который состоит из стандартных спиц диаметром 2 мм, кортикальных винтов и фиксирующей шайбы ориги-нальной конструкции. С помощью шайбы, фиксированной на компактной части кости кортикальным винтом, все ком-поненты имплантата объединяются в единую упруго-напряженную систему, что обеспечивает достаточную прочность фиксации фрагментов. После операции нет необходимости в жесткой иммобилизации, что дает возможность совер-шать активные и пассивные движения в тазобедренном суставе без осевой нагрузки на ногу. Применение нового фик-сатора обеспечит стабильность фиксации, уменьшит контакт имплантата с костью, не требуя травматичной отслойки мягких тканей от костных фрагментов, и позволит рано активизировать больного.Ключевые слова: спицевинтовой фиксатор, упруго-напряженный остеосинтез, биомеханическое обоснование, перелом шейки бедренной кости, тазобедренный сустав.
BIOMECHANICAL GROUNDS FOR APPLYNG THE ELASTIC-TENSE PINSCREW OSTEOSYNTHESIS FOR FEMORAL NECK FRACTURES Kovalev P.V., Dubrovin G.M., Doroshev M.E.
Department of Traumatology and Orthopedics of Kursk State Medical University, KurskIn the article we give a reason of using the new less traumatic method of surgical management of femoral neck fractures. The technique is based on putting into practice a new elastic-tense pinscrew implant, which consists of standard wires 2 mm in diameter, cortical screws, and the holdfast of the original design. With the help of the holdfast all components are integrated in the united elastic-tense system. It provides the sufficient durability of fixing the fragments. There is no need for immobilisation after the surgery, so it gives the possibility to move hip joint without axial tension. The application of the new fixator provides fixation stability, reduces the contact between the implant and the bone without traumatic detachment of soft tissues. Thus, the method will allow making a patient more active.
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