Transgenic mice carrying a hybrid gene consisting of ovine β‐lactoglobulin gene sequences and human γ‐interferon (hIFN‐g) cDNA were produced. hIFN‐g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN‐g in the milk was estimated as being ca. 1800 IU/ml. The hIFN‐g ability to express in the mammary gland was found in the progeny of transgenic founder male.
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