Цель. Определить частоту выявляемости маскированной артериальной гипер-тонии (МАГ) у лиц молодого возраста, а также распространенность и выражен-ность кардиоваскулярных факторов риска с учетом гендерных различий. Материал и методы. Проведено сплошное скринирующее исследование 512 молодых лиц в возрасте 19-30 лет из числа работников учреждений, без регла-ментированных факторов профессиональной вредности, из которых 82,4% -нормотоники и 17,6% пациенты с МАГ. Участникам исследования проводились клинико-лабораторные, инструментальные методы обследования, тест с 30-секундной задержкой дыхания. Результаты. При оценке антропометрических данных -ИМТ, ОТ, ОБ были достоверно выше (р<0,005) у лиц женского и мужского пола с МАГ. У мужчин с МАГ уровень "офисного" артериального давления (АД) имел тенденцию к более высоким показателям "офисного" систолического АД (САД), составля-ющего 130 [128;135] мм рт.ст., чем у женщин с МАГ с уровнем "офисного" САД 124 [120;130] мм рт.ст. и у "нормотоников" -110 [100;120] мм рт.ст. У мужчин с МАГ чаще выявлялись кардиоваскулярные ФР -курение и дислипидемия в 6 раз чаще, чем у женщин с МАГ. Факт наследственной отягощенности превали-ровал среди мужчин с МАГ (85%) по сравнению с женщинами с МАГ (65%). У лиц с МАГ уровень физической активности по сравнению с "нормотониками" был в 2 раза ниже. Мужчины с МАГ чаще досаливали уже приготовленную пищу (57%) и употребляли колбасные изделия (61%), а также чаще потребляли алкогольные напитки. Заключение. Выявляемость МАГ среди молодых мужчин составляет 9,6% и 8% среди молодых женщин. У молодых лиц с МАГ по сравнению с "нормотониками" чаще определяются кардиоваскулярные факторы риска, поражение органов-мишеней, нарушения пищевого поведения. 30-ти летний риск развития атеро-склеротических ССЗ у молодых мужчин с МАГ был более чем 6 раз и у молодых женщин почти в 5 раз выше, чем у "нормотоников" такого же возраста. MASKED HYpERTENSION IN YOUNG pERSONS: pREVALENCE, SIGNIFICANCE OF CARDIOVASCULAR RISK FACTORS AND pROGNOSIS bY GENDER DIFFERENCESLyamina N. P., Nalivaeva A. V., Senchikhin V. N., Lipchanskaya T. P. Aim.To evaluate the prevalence of masked arterial hypertension (MAH) in young persons, as the prevalence and significance of cardiovascular risk factors, taken gender differences. Material and methods. A coverage screening study of 512 young persons age 19-30 y. o. was done, from institutional workers, with no specific professional harm exposures, of those 82,4% -normotonic and 17,6% have MAH. The participants underwent clinical laboratory and instrumental investigations, 30-second breath stop test. Results. In anthropometric measures, body mass index, waist circumference, hips volume were significantly higher (p<0,005) in men and women with AHT. In men with MAH blood pressure (BP) level showed tendency to higher office systolic BP (SBP) as 130 [128;135] mmHg, than in women SBP 124 [120;130] mmHg and normotonics SBP 110 [110;120] mmHg. In men with MAH there were cardiovascular risk factors more common -smoking, dyslipidemia 6 times more prevalent t...
Aim. To assess the neurohumoral state, specifics of clinical presentation, prevalence and prominence of cardiovascular and behavioral risk factors in males of young age with masked arterial hypertension (MAH).Material and methods. To the full coverage screening study, 643 participants included, age 18-30 y. o. (mean age 22). Complete clinical and laboratory, instrumental assessments performed, with analysis of neurohumoral activity by the levels of adrenaline, noradrenaline, angiotensin II. All participants were selected to groups: MAH (n=61), manifest AH (n=46), normotonics (n=536). Diagnostics of MAH was done in case of positive test of 30 second respiration pause and 24 hour blood pressure (BP) monitoring.Results. In males, MAH was found in 9,5% cases, manifest AH in 7,1%, normotonia in 83,4%. In MAH and manifest AH participants the level of adrenaline was higher than in normotonics: 4,55 pM/L [3,53; 5,1], 6,25 pM/L [4,75; 8,65] and 2,1 pM/L [1,2; 4,5], respectively. Males with MAH had almost 2 times higher level of noradrenaline (19,5 pM/L [18,8; 22,8]) comparing to “normotonics” (8 pM/L [6; 12,1]) and 1,5 times higher than in manifest AH (13,1 pM/L [11,5; 14,4]). Angiotensin II assessment showed that in MAH males it was higher (18,5 pM [15,75; 21,9]), than in normotonics (15,7 pM [13;18,3]), but lower than in manifest AH (20,15 pM [18,9; 21,9]). Food related behavior assessment as of a factor of sodium overconsumption, the higher values were found in MAH patients and in manifest AH (50% and 50%) comparing to normotonics (25%). Early age of smoking beginning found in 28% of MAH males, more prevalent than in normotonics (24%) and manifest AH (15%).Conclusion. In young males MAH is revealed more often than manifest AH. Development of MAH in young males is related to hypersympathicity with raised catecholamines level, disordered 24 hour rhythm “non-dipper”, disorder of BP variability and higher smoking level, than in normotonics.
The main topic of the article is the assessment of the endothelial dysfunction and the rigidity of arterial wall in the small, medium and large vessels in young patients with short anamnesis of hypertension and with different variability of blood pressure (BP). In young patients even at the beginning of arterial hypertension (AH) the disturbance in rigidity of arterial walls in great and peripheral vessels occurs. The increased variability of BP in young patients with AH is an aggravating factor of the arterial rigidity disturbances. The assessment of arterial rigidity in young patients at the early stages of the disease can elicit the early signs of endothelial dysfunction
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.