Malignant ascites is a common manifestation of advanced cancers, and treatment options are limited. The trifunctional antibody catumaxomab (anti-epithelial cell-adhesion molecule x anti-CD3) represents a targeted immunotherapy for the intraperitoneal (i.p.) treatment of malignant ascites secondary to epithelial cancers. In this phase II/III trial (EudraCT 2004-000723-15; NCT00836654), cancer patients (n = 258) with recurrent symptomatic malignant ascites resistant to conventional chemotherapy were randomized to paracentesis plus catumaxomab (catumaxomab) or paracentesis alone (control) and stratified by cancer type (129 ovarian and 129 nonovarian). Catumaxomab was administered as an i.p. infusion on Days 0, 3, 7 and 10 at doses of 10, 20, 50 and 150 μg, respectively. The primary efficacy endpoint was puncture-free survival. Secondary efficacy parameters included time to next paracentesis, ascites signs and symptoms and overall survival (OS). Puncture-free survival was significantly longer in the catumaxomab group (median 46 days) than the control group (median 11 days) (hazard ratio = 0.254: p < 0.0001) as was median time to next paracentesis (77 versus 13 days; p < 0.0001). In addition, catumaxomab patients had fewer signs and symptoms of ascites than control patients. OS showed a positive trend for the catumaxomab group and, in a prospectively planned analysis, was significantly prolonged in patients with gastric cancer (n = 66; 71 versus 44 days; p = 0.0313). Although adverse events associated with catumaxomab were frequent, they were manageable, generally reversible and mainly related to its immunologic mode of action. Catumaxomab showed a clear clinical benefit in patients with malignant ascites secondary to epithelial cancers, especially gastric cancer, with an acceptable safety profile.

No abstract

Gold and other heavy minerals often form scaly, leafy, needle-like or split crystals, dendrites of complex shape, individuals and aggregates with a large number of internal cavities. Significant mobility of these particles in water and air streams causes their separation from the psammitic component of sediment and deposition together with clay minerals. During preparatory stages for mineralogical analysis, such crystals of heavy minerals fall into slime part. According to classical algorithm of schlich mineralogical analysis slime part is thrown away. So it leads to losses of rich minerals and an incorrect analysis. The main purpose of the article is to present the new algorithm for the preparation of the bottom sediments samples for the mineralogical analysis and to demonstrate practical benefits of it. Authors propose the meliorated methods of mineralogical analysis considering comprehensive study of test material. The real natural composition of ore minerals in the sediments consists of adding the data "heavy concentrate-1" and "heavy concentrate-2". This provides an increase in industrial value of minerals by 10-30%, compared with the methods of prospecting that operate today. Such detailed analysis showed that modern bottom sediments include both natural components and man-made materials (plastic, polyethylene, synthetic fibers and fabrics, fuel, various types of petroleum products, metallurgical and household waste). Mineralogical analysis can be used as an ecological method for assessing the environmental pollution and reviewing the types of pollutants. The estimation of mineral reserves according to new methodology opens opportunities for profitable field development of poor polymetallic deposits. The study of bottom sediments by such a method indicates the need to clean hydrogeoecosystems and stimulates the development of new recycling methods in the economy and the waste-free production, for example, cleaning beaches from heavy metals and waste, complex sludge processing after dredging works in riverbeds, berths and port waters.

The article discusses the possibility of more efficient use of solar collectors and use in heat supply systems in the Siberian region. The symbiosis of storage and accumulation of solar energy is considered. The development of Novosibirsk scientists on methods of accumulating solar energy was studied, air and water solar collectors were manufactured, tested. It is concluded that collectors can be used to maintain plus energy indoor temperatures, use to heat water; the use of solar collectors may reduce heating costs, which will not be taxed on CO; the use of solar collectors can also significantly reduce the use of natural resources and, as a result, reduce the environmental burden on the environment. Practical significance: the results of the study can be used both in real everyday situations and in physics lessons when studying the transformation of energy and solving practical problems.

79 М.О. Маслаков, В.В. Іванченко, А.С. Ільїна ДНУ «Відділення морської геології та осадочного рудоутворення НАН України», Київ ТОНКЕ ТА ДИСПЕРСНЕ ЗОЛОТЕ ЗРУДЕНІННЯ НА ПІВНІЧНО-ЗАХІДНОМУ УЗБЕРЕЖЖІ ЧОРНОГО МОРЯ Âèвчåíî çîëîòî ç ïðèбåðåжíîìîðñьêèх ³ ð³чêîвèх в³äêëàä³в íà ï³вí³чíîçàх³äíî ìу уçбåðåжж³ ×îðíîãî ìîðя. Ó вåðхí³х ä³ëяíêàх àëюв³àëьíîãî ðîçð³çу çîëîòî ìàє íåвåëèêèé вì³ñò äîì³шîê, уòвîðює òîíê³ ïëàñòèíè ç ч³òêèìè êîíòуðàìè, ñêëà äåí³ íàïëèвàìè, êîëîìîðôíèìè àãðåãàòàìè ç бåçë³ччю ïуñòîò. Ó íèжíьîìу ïðè ïëîòèêîвîìу ³íòåðвàë³ ðîçð³çу äîì³íуюòь щ³ëьí³ ãðуäêувàò³ чàñòî äåôîðìîвàí³ çåðíà ç³ ñð³бëîì òà ³íшèìè äîì³шêàìè. Íàвåäåí³ îñîбëèвîñò³ çîëîòà в äåяê³é ì³ð³ ïîяñíююòь ðåã³îíàëьí³ ïðîбëåìè éîãî вèявëåííя ³ çбàãàчåííя. Ключові слова: àëюв³é, çîëîòîíîñíà àñîц³àц³я, ìîðôîëîã³я çîëîòà. ВсòóпÀëюâіàëьíі òà пðèáåðåжíî-ìîðñьêі піщàíі âіäêëàäè піâíі÷íîãî çàхîäó Чîðíîãî ìîðÿ ìàюòь âåëèêå íàðîäíîãîñпîäàðñьêå çíà÷åííÿ, пåðåäóñіì ÿê áóäіâåëьíèé ìàòåðіàë. В îñòàííіé ÷àñ âñòàíîâëåíà їх çîëîòîíîñíіñòь. Рîáîòàìè óêðàїíñьêèх â÷åíèх âèÿâëåíà Піâäåííîóêðàїíñьêà пðîâіíціÿ òîíêîãî òà пèëîпîäіáíîãî çîëîòà [8].Зðîñòàííÿ óâàãè äî äèñпåðñíîãî òà òîíêîãî çîëîòà âèêëèêàíî âè÷åðпàííÿì çàпàñіâ êîðіííèх òà ðîçñèпíèх ðîäîâèщ çîëîòà. Бàãàòî àâòîðіâ ââàжàюòь, щî XXI ñòîëіòòÿ áóäå ñòîëіòòÿì äèñпåðñíîãî çîëîòà, ÿêå ìîжíà âèëó÷àòè ÿê ñóпóòíіé пðîäóêò пðè âèäîáóâàííі піñêó äëÿ áóäіâíèцòâà, âèðîáíèцòâà ñêëà ÷è іíшèх пîòðåá.Вèâ÷åííÿ пîòåíціéíîї çîëîòîíîñíîñòі Піâíі÷íî-Зàхіäíîãî Пðè÷îðíîìîð'ÿ ÿâëÿє ñîáîю ëîãі÷íå пðîäîâжåííÿ áàãàòîðі÷íèх äîñëіäжåíь, щî пðîâîäèëèñь óêðàїíñьêèìè äîñëіäíèêàìè â ìåжàх піâíі÷íîї ÷àñòèíè àêâàòîðії Чîðíîãî òà Àçîâñьêîãî ìîðіâ, пðèëåãëèх ÷àñòèí ñóхîäîëó і íà Кðèìñьêîìó піâîñòðîâі [2,[6][7][8][9]12]. Вîíî âðàхîâóє ãåîëîãі÷íó áóäîâó піщàíèх âіäêëàäіâ піâíі÷íî-çàхіäíîãî óçáåðåжжÿ Чîðíîãî ìîðÿ, íàÿâíіñòь äîãîëîцåíîâîї ìåðåжі пàëåîðіê, âіêîâі ñпіââіäíîшåííÿ і ëіòîëîãію пðèáåðåжíèх íàäçàпëàâíèх