The ability of perfluorodecalin to improve the properties of blood and protect it from harmful agents was assessed by evaluating the functional state of donor blood treated with this compound and then exposed to O 2 in a bubble (contact) oxygenator. The results of determining the acidic resistance of erythrocytes, serum levels of free hemoglobin, the amount of malonic dialdehyde in lipid extracts of erythrocyte membranes, erythrocyte deformability, and blood viscosity support the notion that organoperfluoric compounds are chemically and biologically inert. Pretreatment of blood with perfluorodecalin protects it from the adverse effects of contact oxygenation and improves its theological properties.
The hemoprotective effect of perfluorocarbons was studied by examining the surface architectonics of red cells during exposure of the blood to perfluorodecalin and contact oxygenation. Scanning electron microscopy revealed an appeciable increase in the percentage of damaged erythrocytes directly exposed to oxygen in a contact oxygenator. Interaction between blood and perfluorodecalin not only does not impair the morphology of the blood, but also prevents untoward effects of subsequent contact oxygenation. Fluorocarbon treatment of the blood gives rise to a number (up to 17-18%) of special cells, which morphologically represent somewhat altered normocytes with increased resistance, this reflecting a specific reaction of the blood to perfluorodecalin.
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