The aim of the study was to study the possibility of predicting the shape of the obturator foramen depending on the shape of the pelvic bone cavity in the aspect of the surgical treatment of stress urinary incontinence in adult women. Materials and methods. 61 preparations of the female bone pelvis were studied. A pelviometric form was developed, according to which the linear and angular parameters of the pelvis and obturator foramen, indices of the pelvic cavity and obturator foramen were evaluated. A discriminant analysis was applied to classify the shapes of the obturator foramen. Results. Based on the calculated pelvic cavity indices, the shape of the pelvic cavity was determined: narrowing to the bottom, cylindrical and widening to the bottom. Using discriminant analysis, a model was developed to predict the shape of the obturator foramen, depending on the shape of the pelvis. Two main forms of the obturator foramen are distinguished: triangular and elliptical. It was found that the triangular form of the obturator foramen is most characteristic of the cylindrical form of the pelvic cavity and to a lesser extent of the downwardly tapering form. The ellipsoidal shape of the obturator foramen predominated in the downwardly expanding pelvic cavity. It is also shown that a narrow under-pelvic angle is characteristic of the downward pelvic cavity and a wide under-pelvic angle is characteristic of the downward dilating pelvis. Conclusion. The presented index of the lateral deviation of the ischial tubercles makes it possible to determine the shape of the pelvic cavity: narrowing to the bottom, cylindrical and dilating to the bottom. The method of discriminant analysis provides a high degree of certainty in predicting the shape of the obturator foramen, depending on the shape of the pelvic cavity.
Purpose. To reflect the current understanding of the frequency, molecular mechanisms, and means of overcoming alopecia in cancer patients, taking into account the fundamental data of recent years on the physiology of the hair follicle and the pharmacological profile of the toxicity of anticancer drugs.Material and Methods. A literature search using Medline, Pubmed, etc. databases was carried out. More than 200 publications devoted to the study of alopecia were found, of which 42 were included in this review.Results. Chemotherapy-induced hair loss is a common adverse effect in cancer patients undergoing treatment. The frequency and molecular mechanism of the development of alopecia are related to the pharmacological features of the drug-based treatments, initial nutritional premorbid status, and predisposing polymorphisms of genes involved in drug conversion and excretion. Focal or diffuse alopecia may be the first sign of malignant growth within the paraneoplastic syndrome, primary or metastatic malignancies of the scalp, or be a manifestation of nutritional insufficiency. Baldness negatively affects the psycho-emotional state of patients, exacerbating depressive disorders, anxiety, reducing self-esteem and adherence to treatment. Thus, prevention or rapid overcoming of alopecia can significantly improve the quality of life of cancer patients. The use of scalp cooling or ‘cold caps’ is proven to be an effective way of combating chemotherapy-induced hair loss.Conclusion. Further studies are needed to prevent and treat alopecia in cancer patients.
Aim. To demonstrate the advantages of laparoscopic surgery in patients with colorectal cancer compared to traditional surgical intervention. Methods. A retrospective analysis of 40 patients treatment (the main group) in the Department of abdominal Oncology of the Kursk Regional Oncology Center for the period 20172019, who had a pronounced violation of the passage through the intestine due to stenosing by the tumour, was conducted. As a control group, 30 people who underwent open surgery in the volume of a colostomy for the period 20172019 was taken. Results. According to the average duration of surgical intervention, the groups significantly differed (p 0.05), the average duration of surgery in the laparoscopic group was less 40.513.6 min, with laparotomy 54.518.5 min. The volume of blood loss during the operation was greater in the control group and reached 7540 ml against, 10.55.5 ml the differences were statistically significant (p 0.05). The average length of stay in hospital in the laparoscopic group was 41 days, which is significantly less than in patients who underwent laparotomy 114 days (p 0.05). Postoperative complications occurred in 10% of patients in the control group: seroma of the median wound in 2 patients, ligature fistula in 1 patient. There were no postoperative fatalities in both groups. Conclusion. The comparison of methods of surgical intervention showed that the results of laparoscopic operations are much better than traditional open operations in patients with colorectal cancer since they significantly reduce the duration of the rehabilitation period, accompanied by minor blood loss.
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