Objective: to study the plasma levels of steroid hormones and the rates of neurological recovery in the early postresuscitative peri od after 10 min cardiac arrest in albino male and female rats in the control group and in the study group receiving estradiol + dehy droepiandrosterone. Materials and methods. Forty eight animals of both sexes that had experienced under ether anesthesia a 10 min cardiac arrest due to intrathoracic ligation of its vascular fascicle were examined. After standard cardiopulmonary resuscitation, placebo was intramuscularly injected in 31 animals and 17 animals received estradiol and dehydroepiandrosterone in a dose of 0.1 mg and 5 mg per 100 g of ginodian depot (Shering, Germany) used for prolonged correction of the postcastration syndrome in women. Then the general and neurological statuses were evaluated in the animals. Enzyme immunoassay was used to determine the plasma concentration of 7 sex steroids in normalcy (18 intact animals), in the control animals in the untreated animals (n=31) on days 2 and 16 following resuscitation and in the hormone treated (n=17) animals only on day 16. Results. The processes of dying and cardiovascular resuscitation did not differ significantly in the male and female groups. During the days which followed, there was a more rapid neurological recovery in female rats as compared with male rats in both the control group and the hormonal treatment group with the accelerated external recovery in the latter. There were significant gender differences in the plasma hormonal profile in normalcy and in the postresuscitative period in the controls, which were leveled after treatment. Conclusion. The gender differences in the results of postresuscitative recovery are associated with the specific features of the pro file of endogenous reproductive steroids in the organism. Functional recovery following clinical death may be accelerated by exogenous sex steroids.
The purpose of the article is to determine the ways of development of hotel
and restaurant business in the period of post-war reconstruction of Ukraine.
The research methodology is based on the use of general scientific and specific
methods, in particular: analysis and synthesis, induction and deduction, modeling,
systematization and generalization.The scientific novelty of the obtained results lies in the substantiation and proposals for the creation of smart cities within hotel and restaurant complexes.
Conclusions. The article establishes that the hotel and restaurant business suffers
significant losses during the war. It is proved that in the post-war period it is
necessary to develop development strategies that will counteract internal and
external risks. The main strategies for the development of the hotel and restaurant
business in the postwar period are systematized. In particular, two groups of
development strategies have been identified: the strategy of maintaining a positive
image in the market and the strategy of overcoming the negative post-war
consequences. There are 10 signs on the basis of which it is possible to assert the
existence of smart cities within the hotel and restaurant business. The strategy for
the development of the hotel and restaurant business should be formed taking into
account current development trends. To do this, it is necessary to develop approaches
that would reduce the level of risk caused by the emergence of negative customer
expectations. To do this, a marketing and sales strategy must be used. The main
role will be played by corporate culture, which will be the core of future strategic
changes. Important for implementation is the innovation strategy, the implementation
of which should take place through the creation of smart cities within the hotel
and restaurant complex. This approach minimizes contact with the external
environment and promotes a positive impression of the quality of services.
Key words: hotel and restaurant business, strategies of hotel and restaurant
business development, business risks, hotel and restaurant complexes, smart city.
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