Geological ring structures of various sizes and ori gins are observed on the Earth's surface. In the past decade, ice ring structures on Lake Baikal were regu larly identified by satellites [1]. On April 4, 2009, these structures emerged in the western end of South Baikal and near the Svyatoi Nos Peninsula in Central Baikal [1][2][3] and were destroyed along with the ice at the end of April. The expedition for studying the ice and hydrophysical measurements in the area of the ring structure in South Baikal was organized on April 7. This work presents the results of the field studies and modeling of the currents and variations in the ice thickness.The MODIS satellite data in the visible range with a spatial resolution of 250 m (www.geol.irk.ru) were used for remote study of the ring structure. During the field studies, the ice thickness was measured and the ice cores were drilled along two sections, which transect the center of the ring structure at 51°40′35″ N, 103°52′15″ E (Fig. 1a). The measurement stations were placed in the center of the structure and 1, 2, 3, and 4 km from it along the sections and 7 and 8 km to the west and to the east, respectively, from the center along the EW section. The ice surface in the center of the structure, at its periphery, and in the area of the dark ring was visually similar. No water was visible on the ice surface, and the ice was made up of vertical crys tals. The ice thickness was 74 cm in the center, decreased to 43 cm at the distance of 2 km from the center, and increased up to more than 70 cm beyond the ring.The temperature and electric conductivity of the water column were registered by a SBE 19 profiler. The water in the center was warmer by 0.5°С and less saline (for 2 mg/kg) relative to the periphery (Fig. 1b). In spite of the higher temperature in the center, the ice thickness was similar to that beyond the structure; i.e., the temperature of the water layer was not the major factor responsible for the decrease in the ice thickness. The deepening of the thermocline in the center of the structure (Fig. 1b) indicated the presence of the ring anticyclonic current.According to the tracer movements, the maximum velocities of the water currents (3-4 cm/s) were observed at a distance of 2-3 km from the center of the Abstract-This work presents the results of complex analysis of the field data and of mathematical modeling of the ice ring structure more than 4 km across, which was identified by the space images of South Baikal in April 2009. The measurements revealed that the ice thickness was 74 cm in the center of the structure, decreased to 43 cm at a distance of 2 km, and increased up to 70 cm and more beyond the ring. The ice water in the central part was warmer by 0.5°C and less saline (for 2 mg/kg) relative to the periphery of the structure. According to the tracer movements, the maximum velocities of the ice currents (3-4 cm/s) were observed at a distance of 2-3 km from the center of the structure with minimum ice thickness. The event was modeled using several mathem...
Stem cell-based therapy is considered to be a new approach for the treatment of cerebral palsy (CP). Given the potent anti-inflammatory activity and high regenerative potential of M2 macrophages, these cells may be an alternative source for cell transplantation. To evaluate the safety and efficacy of autologous M2 macrophages, we conducted a pilot clinical trial in 21 children with severe CP. The primary outcome measure was safety, which included assessment of mortality of any cause, immediate adverse reactions, and serious adverse effects and comorbidities during 5-year follow-up. The secondary outcome measure was functional improvement in Gross Motor Function Measure (66-item GMFM) test, Peabody Developmental Motor Scale-Fine Motor (PDMS-FM) test, Ashworth scale, MRC scale, and an easy-to-understand questionnaire for evaluation of cognitive functions in our modification. Intradural injection of M2 cells (in mean dose of 0.8 × 10(6)/kg) into the lumbar spinal area did not induce any serious adverse events. No cases of mortality, psychomotor worsening, exacerbation of seizures, and long-term comorbidities, including tumors, were observed during a 5-year follow-up. After 3 months, GMFM score increased from 13.7 ± 7.8 to 58.6 ± 14.6, PDMS-FM score improved from 0.76 ± 0.42 to 5.05 ± 0.97, and the Ashworth score decreased from 3.8 ± 0.21 to 3.3 ± 0.24. Along with gross and fine motor function enhancement, an improvement of cognitive activity (from 1.62 ± 0.41 to 4.05 ± 0.64, according to questionnaire assessment) and reduction of seizure syndrome were registered as well. The neurological improvements did not diminish during the 5-year follow-up period. The data obtained suggest that cell therapy based on M2 macrophages is safe, does not induce early adverse effects and long-term comorbidities, and is accompanied with a significant improvement of motor and cognitive activities in severe CP patients. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.
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