40 patients with alcohol dependence in post-abstinent period was used to study the psychological peculiarities of emotional-motivational sphere during the course of placebo therapy. The placebo-reactor was 62.5%, placebo preaction – 15%, placebo-negative reactors of 22.5%. There are significant differences in the compared groups of patients. After a course of placebo-therapy all patients showed positive changes in emotional state, most pronounced in placebo-directoru. The least pronounced changes in the placebo group-negative patients (but to lessen the desire for alcohol most pronounced). The conclusion about the need for a differentiated approach to the treatment of alcohol withdrawal syndrome and postdetoxification state.
гипоксен в терапии астенического состояния при алкогольной зависимости © в. в. востриков ГБоУ вПо «Санкт-Петербургский государственный педиатрический медицинский университет» минздрава россии Резюме. в настоящее время необходимость комплексного подхода к лечению больных с аддиктивной патологией не вызывает никаких возражений. выбор фармакологических препаратов, используемых для купирования проявлений болезни на различных этапах достаточно широк. Это диктует необходимость оптимизировать лечебные подходы, применять дифференцированные комплексные программы, направленные на использование определенной фарма-котерапии у различных групп больных. в последние годы большой интерес вызвали фармакологические средства и методы, улучшающие утилизацию организмом циркулирующего в нем кислорода, уменьшающие потребность в кис-лороде органов и тканей и тем самым способствующие уменьшению гипоксии и повышению устойчивости организ-ма к кислородной недостаточности. Гипоксен (полидигидрокси-фенилентиосульфонат натрия) с 1996 года разрешен к медицинскому применению. Гипоксен способен как увеличивать эффективность использования кислорода за счет сопрягающего эффекта, обусловленного специфическим взаимодействием с первым комплексом дыхательной цепи митохондрий, так и изменять конформацию порфирина, что приводит к снижению сродства к кислороду. одновре-менно происходит модификация ионотранспортных систем эритроцита. в результате связанный гемоглобином кис-лород легче десорбируется и диффундирует в клетки, а со 2 , напротив, более интенсивно связывается порфириновым комплексом эритроцита. в нашем исследовании проводили двойное слепое плацебо-контролируемое рандомизиро-ванное сравнительное клиническое исследование эффективности гипоксена (0,5 г/сутки, 14 дней) после купирования синдрома отмены алкоголя у 40 больных с алкогольной зависимостью. выявлено выраженное влияние препарата на эмоционально-мотивационный статус больных. сделан вывод о высокой эффективности применения гипоксена у данной группы больных в постабстинентном периоде. Abstract. At present the need for a comprehensive approach to the treatment of patients with addictive disorders unchallenged. The choice of pharmacological agents used for the relief of symptoms of the disease at different stages is quite wide. This indicates for the need to optimize the therapeutic approaches to apply differentiated complex programs for using a specific drug therapy in different groups of patients. In recent years the great interest was attracted to pharmacological means and methods for improving utilization by the organism of oxygen circulating in it, reducing the oxygen demand of organs and tissues, thereby contributing to reduction of hypoxia and increase resistance to oxygen deficiency. Hypoxenum was allowed for medical use since 1996 year. Hypoxenum is able to both increase efficiency of oxygen use by mechanism of coupling effect due to a specific interaction with a first set of the respiratory chain of mitochondria and alter the conformation of the porphyrin resulting in decreased affini...
Sociological surveys show that the average age of drug users in recent years has drastically decreased from 18 years to 13 years. Among children of aged from 5 to 7 years the episodes of drug use have been reported. At the same time their parents addicts contribute to this. Statistics show that more than 60 % of drug addicts are young people aged from 17 to 35 years. More than 20 % are children, students, and only 15 % are people older than 35 years. The use by mother during pregnancy psychoactive substances (PAS) is one of the major risk factor for congenital addiction. The most important risk factors for drug abuse are genetic ones. There are two main genetically dependent factors. The first factor is genetically determined high level of the dopamine which encourage a person on a constant search for new sensations, dissatisfaction peace, and search risky situations. The second one is a low level of the hormone serotonin which results in depression in stressful situations. The stressful situations become very deep. Certain factors increase the risk of addictive behavior of offspring may appear at birth. Many people who started the abuse at early age consciously preferred drug to alcohol. That is the adoption of alcohol caused them to aversion to alcohol because of the memories of his father-alcoholic. However based on the biological characteristics while it is not so easy to predict the likelihood of addiction and clearly define in advance the tendency or, on the contrary, human resistance to drug intoxication and dependence.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.